PTEN and Gynecological Cancers.
PTEN
cervical cancer
endometrial cancer
ovarian cancer
uterine cancer
vulvar cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Sep 2019
28 Sep 2019
Historique:
received:
13
08
2019
revised:
16
09
2019
accepted:
24
09
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
2
10
2019
Statut:
epublish
Résumé
PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. It is involved in a great variety of biological processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. A better understanding of PTEN activity and regulation has therefore emerged as a subject of primary interest in cancer research. Gynaecological cancers are variously interested by PTEN deregulation and many perspective in terms of additional prognostic information and new therapeutic approaches can be explored. Here, we present the most significant findings on PTEN in gynaecological cancers (ovarian, endometrial, cervical, vulvar and uterine cancer) focusing on PTEN alterations incidence, biological role and clinical implications.
Identifiants
pubmed: 31569439
pii: cancers11101458
doi: 10.3390/cancers11101458
pmc: PMC6826459
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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