Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model.
PLGA polymer
curcumin
curcumin release
mice xenograft model
prostate cancer
supercritical carbon dioxide impregnation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Sep 2019
29 Sep 2019
Historique:
received:
10
09
2019
revised:
24
09
2019
accepted:
26
09
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
4
3
2020
Statut:
epublish
Résumé
Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its incidence/prevalence and improve survival rates. One of the most promising extracts is curcumin, which is a major, nontoxic, bioactive compound of
Identifiants
pubmed: 31569529
pii: nu11102312
doi: 10.3390/nu11102312
pmc: PMC6835253
pii:
doi:
Substances chimiques
Capsules
0
Plant Extracts
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : Ramón y Cajal Fellowships RyC-2014-16307
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