Nanoparticles Targeting STATs in Cancer Therapy.
STAT3
bioavailability
cancer therapy
drug delivery
nanoparticle
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 09 2019
27 09 2019
Historique:
received:
16
08
2019
revised:
20
09
2019
accepted:
25
09
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
1
7
2020
Statut:
epublish
Résumé
Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy.
Identifiants
pubmed: 31569687
pii: cells8101158
doi: 10.3390/cells8101158
pmc: PMC6829305
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
STAT Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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