Impedance and conductivity of bovine myocardium during freezing and thawing at slow rates - implications for cardiac cryo-ablation.
Cryo-ablation
Electrode polarization
Osmotic virial equation
Tissue impedance
Journal
Medical engineering & physics
ISSN: 1873-4030
Titre abrégé: Med Eng Phys
Pays: England
ID NLM: 9422753
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
01
2019
revised:
12
09
2019
accepted:
16
09
2019
pubmed:
2
10
2019
medline:
21
5
2020
entrez:
2
10
2019
Statut:
ppublish
Résumé
Increasing impedance during freezing might be a valuable marker for guiding cardiac cryo-ablation. We provide model based insights on how decreasing temperature below the freezing point of tissue relates to the percentage of frozen water. Furthermore, we provide experimental data for comparing this percentage with the increase in impedance. Measurements were performed on a bovine tissue sample at frequencies between 5 and 80 kHz. Slow cooling and heating rates were applied to minimize temperature gradients in the myocardial sample and to allow accurate assessment of the freezing point. Computer simulation was applied to link impedance with temperature dependent conductivities. The osmotic virial equation was used to estimate the percentage of frozen water. Measurements identified the freezing point at -0.6
Identifiants
pubmed: 31570217
pii: S1350-4533(19)30193-6
doi: 10.1016/j.medengphy.2019.09.017
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-98Informations de copyright
Copyright © 2019 IPEM. All rights reserved.