BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.
Animals
Apoptosis
/ physiology
Binding Sites
Carrier Proteins
/ metabolism
Cytochromes
/ metabolism
Cytosol
/ metabolism
Dimerization
Humans
Kinetics
Mitochondria
/ metabolism
Protein Binding
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Signal Transduction
bcl-2-Associated X Protein
/ metabolism
Journal
Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Titre abrégé: Cold Spring Harb Perspect Biol
Pays: United States
ID NLM: 101513680
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
2
10
2019
medline:
3
8
2021
entrez:
2
10
2019
Statut:
epublish
Résumé
The BCL-2 family of proteins control a key checkpoint in apoptosis, that of mitochondrial outer membrane permeabilization or, simply, mitochondrial poration. The family consists of three subgroups: BH3-only initiators that respond to apoptotic stimuli; antiapoptotic guardians that protect against cell death; and the membrane permeabilizing effectors BAX, BAK, and BOK. On activation, effector proteins are converted from inert monomers into membrane permeabilizing oligomers. For many years, this process has been poorly understood at the molecular level, but a number of recent advances have provided important insights. We review the regulation of these effectors, their activation, subsequent conformational changes, and the ensuing oligomerization events that enable mitochondrial poration, which initiates apoptosis through release of key signaling factors such as cytochrome
Identifiants
pubmed: 31570337
pii: cshperspect.a036319
doi: 10.1101/cshperspect.a036319
pmc: PMC7111251
pii:
doi:
Substances chimiques
BOK protein, human
0
Carrier Proteins
0
Cytochromes
0
Proto-Oncogene Proteins c-bcl-2
0
bcl-2-Associated X Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
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