Long-term Outcome of 181 Patients With Liposarcomas of the Extremity and Truncal Wall.
Liposarcomas
extremity
margins
surgery
survival
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
25
08
2019
revised:
10
09
2019
accepted:
11
09
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
8
10
2019
Statut:
ppublish
Résumé
Liposarcomas (LS) are one of the most common entities within the heterogenous group of soft tissue sarcomas. The aim of this study was to identify prognostic indicators in patients with LS of the extremities and truncal wall. We analysed the influence of potential prognostic factors on local recurrence-free survival (LRFS) and overall survival (OS) in 181 patients who were suitable for surgical treatment with curative intent. The median follow-up period was 7.1 years. The 5-year LRFS and OS rates were 79.1 and 93.3%. The 5-year OS rate was 94.7% in patients with R0-resected primary tumors and 72.7% in patients with R1/R2-status (p=0.023). In multivariate analysis, only histologic grade was found to be an independent prognostic factor of OS. Negative margins were not an independent prognostic factor in our series. Tumor biology reflected by histologic grade dictated the outcome.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Liposarcomas (LS) are one of the most common entities within the heterogenous group of soft tissue sarcomas. The aim of this study was to identify prognostic indicators in patients with LS of the extremities and truncal wall.
PATIENTS AND METHODS
METHODS
We analysed the influence of potential prognostic factors on local recurrence-free survival (LRFS) and overall survival (OS) in 181 patients who were suitable for surgical treatment with curative intent.
RESULTS
RESULTS
The median follow-up period was 7.1 years. The 5-year LRFS and OS rates were 79.1 and 93.3%. The 5-year OS rate was 94.7% in patients with R0-resected primary tumors and 72.7% in patients with R1/R2-status (p=0.023). In multivariate analysis, only histologic grade was found to be an independent prognostic factor of OS.
CONCLUSION
CONCLUSIONS
Negative margins were not an independent prognostic factor in our series. Tumor biology reflected by histologic grade dictated the outcome.
Identifiants
pubmed: 31570477
pii: 39/10/5747
doi: 10.21873/anticanres.13776
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5747-5753Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.