Double-Hydrophilic Block Copolymers Based on Functional Poly(ε-caprolactone)s for pH-Dependent Controlled Drug Delivery.
Antineoplastic Agents
/ administration & dosage
Click Chemistry
Doxorubicin
/ administration & dosage
Drug Carriers
/ administration & dosage
Drug Delivery Systems
Drug Liberation
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Lactones
/ chemistry
MCF-7 Cells
Micelles
Molecular Weight
Polyesters
/ chemistry
Polyethylene Glycols
/ chemistry
Polymers
/ administration & dosage
Solutions
Journal
Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
pubmed:
2
10
2019
medline:
16
4
2021
entrez:
2
10
2019
Statut:
ppublish
Résumé
The use of double-hydrophilic block copolymers (DHBCs) in biomedical applications is limited by their lack of degradability. This additional functionality has been obtained in the past through multistep chemical strategies associated with low yields. In this work, a series of DHBCs composed of a bioeliminable poly(ethylene glycol) (PEG) block and hydrolyzable functional poly(ε-caprolactone) (PCL) blocks bearing carboxylic (PEG-
Identifiants
pubmed: 31571489
doi: 10.1021/acs.biomac.9b01006
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Lactones
0
Micelles
0
Polyesters
0
Polymers
0
Solutions
0
poly(ethylene glycol)-block-poly(epsilon-caprolactone)
0
polycaprolactone
24980-41-4
Polyethylene Glycols
3WJQ0SDW1A
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM