Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis.
apoptosis
cell cycle arrest
colorectal cancer
programmed death-1 ligand 1 (PD-L1)
trifluoperazine hydrochloride
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
02
2019
accepted:
12
08
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
2
10
2019
Statut:
epublish
Résumé
Repurposing existing drugs for cancer treatment is an effective strategy. An approved antipsychotic drug, trifluoperazine (TFP), has been reported to have potential anticancer effects against several cancer types. Here, we investigated the effect and molecular mechanism of TFP in colorectal cancer (CRC).
Identifiants
pubmed: 31572198
doi: 10.3389/fphar.2019.01029
pmc: PMC6753363
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1029Informations de copyright
Copyright © 2019 Xia, Jia, Xue, Jiang, Xie, Wang, Ran, Xu, Zhang and Ye.
Références
Int J Mol Med. 2018 Apr;41(4):1958-1966
pubmed: 29328428
Antimicrob Agents Chemother. 2016 May 23;60(6):3717-29
pubmed: 27067323
Cochrane Database Syst Rev. 2004;(1):CD003545
pubmed: 14974020
Sci Rep. 2014 Aug 12;4:6031
pubmed: 25112436
J Mol Signal. 2010 Jul 19;5:10
pubmed: 20642839
Science. 2001 Apr 27;292(5517):727-30
pubmed: 11326099
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Oncogene. 2003 Nov 24;22(53):8590-607
pubmed: 14634621
Front Immunol. 2017 Aug 10;8:961
pubmed: 28848559
Cell Death Differ. 2016 May;23(5):759-75
pubmed: 26768662
Gastroenterol Rep (Oxf). 2015 Nov;3(4):289-97
pubmed: 26510455
Biomed Pharmacother. 2019 Feb;110:312-318
pubmed: 30522017
Trends Pharmacol Sci. 2013 Sep;34(9):508-17
pubmed: 23928289
Nat Rev Drug Discov. 2015 Sep;14(9):603-22
pubmed: 26228631
Oncotarget. 2019 Mar 12;10(21):2055-2067
pubmed: 31007848
Int J Immunopharmacol. 1991;13(7):961-8
pubmed: 1684786
Cell Res. 2019 May;29(5):347-364
pubmed: 30948788
Am J Respir Crit Care Med. 2012 Dec 1;186(11):1180-8
pubmed: 23024022
J Mol Med (Berl). 2013 Sep;91(9):1029-37
pubmed: 23636511
Oncotarget. 2017 Jun 6;8(23):37568-37583
pubmed: 28455961
Oncotarget. 2016 Jul 5;7(27):42110-42125
pubmed: 27283899
Oncotarget. 2014 Aug 30;5(16):6558-72
pubmed: 25115382
DNA Cell Biol. 2017 Oct;36(10):813-821
pubmed: 28876084
Cancer Res. 2016 Feb 15;76(4):877-90
pubmed: 26627008
Nature. 1999 Jun 3;399(6735):483-7
pubmed: 10365962
Curr Allergy Asthma Rep. 2013 Feb;13(1):44-9
pubmed: 22956391
Cancer Lett. 2018 Aug 1;428:173-183
pubmed: 29729291
Cancer Lett. 2014 Dec 28;355(2):297-309
pubmed: 25301449
Cell Death Dis. 2018 Sep 26;9(10):1006
pubmed: 30258182
Signal Transduct Target Ther. 2018 Jul 1;3:18
pubmed: 29967689
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
J Clin Invest. 2012 Jul;122(7):2637-51
pubmed: 22653055
Med Sci Monit. 2017 Jul 17;23:3461-3469
pubmed: 28713151
Science. 2017 Mar 31;355(6332):1428-1433
pubmed: 28280247
Mol Pharmacol. 2015;87(3):501-12
pubmed: 25552486
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
J Mol Med (Berl). 2019 May;97(5):647-658
pubmed: 30848296
J Cell Biochem. 2018 Jul;119(7):6216-6230
pubmed: 29663486
Cell Prolif. 2003 Jun;36(3):131-49
pubmed: 12814430
Nat Rev Cancer. 2005 Nov;5(11):876-85
pubmed: 16239906
Expert Rev Mol Med. 2008 Jul 01;10:e19
pubmed: 18590585
Oncotarget. 2015 Jan 20;6(2):969-78
pubmed: 25504439
Front Physiol. 2018 May 15;9:500
pubmed: 29867548
Am J Cancer Res. 2019 Mar 01;9(3):459-478
pubmed: 30949404
Trends Cell Biol. 2003 Feb;13(2):65-70
pubmed: 12559756
Oncotarget. 2017 Dec 8;9(5):5979-5992
pubmed: 29464048
Dev Cell. 2008 Feb;14(2):159-69
pubmed: 18267085
World J Gastroenterol. 2012 Jan 7;18(1):25-33
pubmed: 22228967
Pharmacol Rev. 2006 Sep;58(3):621-81
pubmed: 16968952
Nat Rev Immunol. 2008 Apr;8(4):279-89
pubmed: 18340345
Cancer Res. 2018 Jul 15;78(14):3865-3876
pubmed: 29769195
Oncotarget. 2015 Sep 22;6(28):25308-19
pubmed: 26320171
Apoptosis. 2000 Nov;5(5):415-8
pubmed: 11256882
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Br J Cancer. 2006 Oct 9;95(7):934-9
pubmed: 16926836
J Clin Invest. 2019 Mar 1;129(3):1211-1228
pubmed: 30589644
Oncogene. 2005 Oct 6;24(44):6719-28
pubmed: 16007163
Mol Cancer Ther. 2017 Jan;16(1):217-227
pubmed: 28062709
Cancer Lett. 2017 May 1;393:16-21
pubmed: 28188816
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
Free Radic Biol Med. 2010 Mar 15;48(6):749-62
pubmed: 20045723