Persistence of a T Cell Infiltrate in Human Ganglia Years After Herpes Zoster and During Post-herpetic Neuralgia.
ganglia
herpes zoster (HZ)
immune cell
post-herpetic neuralgia (PHN)
varicella-zoster virus
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
05
2019
accepted:
28
08
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
2
10
2019
Statut:
epublish
Résumé
Varicella-zoster virus (VZV) is a human herpesvirus which causes varicella (chicken pox) during primary infection, establishes latency in sensory ganglia, and can reactivate from this site to cause herpes zoster (HZ) (shingles). A major complication of HZ is a severe and often debilitating pain called post-herpetic neuralgia (PHN) which persists long after the resolution of the HZ-associated rash. The underlying cause of PHN is not known, although it has been postulated that it may be a consequence of immune cell mediated damage. However, the nature of virus-immune cell interactions within ganglia during PHN is unknown. We obtained rare formalin fixed paraffin embedded sections cut from surgically excised ganglia from a PHN-affected patient years following HZ rash resolution. VZV DNA was readily detected by qPCR and regions of immune infiltration were detected by hematoxylin and eosin staining. Immunostaining using a range of antibodies against immune cell subsets revealed an immune cell response comprising of CD4
Identifiants
pubmed: 31572325
doi: 10.3389/fmicb.2019.02117
pmc: PMC6749866
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2117Informations de copyright
Copyright © 2019 Sutherland, Steain, Buckland, Rodriguez, Cunningham, Slobedman and Abendroth.
Références
Viruses. 2018 Jun 28;10(7):
pubmed: 29958408
Int J Clin Pract. 2014 Jul;68(7):900-18
pubmed: 24698515
J Virol. 2014 Mar;88(5):2704-16
pubmed: 24352459
Lancet Neurol. 2007 Nov;6(11):1015-28
pubmed: 17945155
J Virol. 2003 Jun;77(12):6979-87
pubmed: 12768016
J Am Geriatr Soc. 2007 Aug;55(8):1168-75
pubmed: 17661954
BMJ Open. 2014 Jun 10;4(6):e004833
pubmed: 24916088
Nature. 2002 May 2;417(6884):95-8
pubmed: 11986671
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10980-4
pubmed: 7479921
J Pain. 2008 Jan;9(1 Suppl 1):S19-30
pubmed: 18166462
Pain. 1988 Aug;34(2):129-38
pubmed: 3174152
Ann Neurol. 1994;35 Suppl:S38-41
pubmed: 8185295
Nature. 1983 Dec 1-7;306(5942):478-80
pubmed: 6316159
Pain Med. 2008 Apr;9(3):348-53
pubmed: 18366512
Ann Neurol. 1987 Sep;22(3):377-80
pubmed: 2823688
Pain. 1991 Aug;46(2):195-9
pubmed: 1749643
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4658-62
pubmed: 9539794
Int J Infect Dis. 2015 May;34:126-31
pubmed: 25841633
Clin Geriatr Med. 2007 Aug;23(3):615-32, vii-viii
pubmed: 17631237
J Virol. 2005 Nov;79(22):14079-87
pubmed: 16254342
J Virol. 2000 Dec;74(24):11464-71
pubmed: 11090142
Pain. 1991 Feb;44(2):105-17
pubmed: 1711192
Cochrane Database Syst Rev. 2014 Feb 06;(2):CD006866
pubmed: 24500927
J Pain. 2004 Aug;5(6):344-56
pubmed: 15336639
J Virol. 2010 Sep;84(17):8861-70
pubmed: 20573825
Pain. 1988 Dec;35(3):289-97
pubmed: 2852344
Lancet. 1983 Oct 8;2(8354):814-6
pubmed: 6137648
J Virol. 1999 Dec;73(12):10514-8
pubmed: 10559370
J Virol. 1999 Oct;73(10):8571-7
pubmed: 10482610
Surg Neurol. 1978 Jul;10(1):50-3
pubmed: 684607
J Virol. 2012 Jan;86(1):578-83
pubmed: 22013055
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2767-70
pubmed: 2833752