Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents.
FTO
body fat
body mass index
gene expression
obesity
skeletal muscle
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
25
02
2018
accepted:
25
05
2018
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
2
10
2019
Statut:
ppublish
Résumé
The modifying effect of FTO gene expression level on change in body mass index and body composition has not been studied before. This study aimed to investigate the association between change in the expression level of the FTO gene and changes in anthropometric measurements in obese and overweight adolescent boys. Eighty-four boys aged 12 to 16 years participated in this longitudinal study. A Bio Impedance Analyzer (BIA) was used to estimate percentage of body fat (%BF) and percentage of skeletal muscle (%SM). The FTO gene expression level in peripheral blood mononuclear cells was assessed using quantitative real-time PCR (qPCR). All measurements were performed at baseline and after 18 weeks. After 18 weeks, mean weight was reduced by 2.39 kg, body mass index by 0.09 kg/m FTO gene expression change was associated with change in %SM in male adolescents. Future studies are required to assess the interactions between FTO gene expression in different tissues and body composition.
Identifiants
pubmed: 31572457
doi: 10.5114/aoms.2019.87239
pii: 37432
pmc: PMC6764316
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1133-1137Informations de copyright
Copyright: © 2019 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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