Prognostic Value of Blood Lactate and Base Deficit in Refractory Cardiac Arrest Cases Undergoing Extracorporeal Life Support.
Base deficit
blood lactate
extracorporeal life support
prognosis
refractory cardiac arrest
Journal
Turkish journal of anaesthesiology and reanimation
ISSN: 2667-677X
Titre abrégé: Turk J Anaesthesiol Reanim
Pays: Turkey
ID NLM: 101680817
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
28
07
2018
accepted:
26
09
2018
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
2
10
2019
Statut:
ppublish
Résumé
Cardiac arrest (CA) resuscitation is associated with an 'ischaemia-reperfusion' syndrome characterised by lactic acidosis as assessed by lactate and base deficit (BD). Both biomarkers are usually measured in patients suffering from refractory CA (RCA) subjected to extracorporeal life support (ECLS) to evaluate tissue reperfusion. However, their prognostic value has never been compared. The aim of the present study was to compare the prognostic value of both biomarkers measured at 0 and 3 h after the initiation of ECLS in patients with RCA on mortality. Patients who were admitted to the intensive care unit with RCA were consecutively included in the study. Sixty-six patients were included. Lactate correlated with BD (R2=0.44, p<0.001). An area under the curve of 0.72 (95% confidence interval (CI) 0.59-0.84) was found for lactate and of 0.60 (95% CI 0.46-0.73) for BD. Using multivariable logistic regression, lactate (odds ratio (OR) 1.22, 95% CI 1.03-1.48) remained associated with mortality on day 28, but not BD (OR 0.99, 95% CI 0.86-1.14). We report a difference in the prognostic value of lactate and BD on mortality. Three hours from the initiation of ECLS in patients with RCA, lactate should be preferred to BD to predict the efficiency of ECLS.
Identifiants
pubmed: 31572993
doi: 10.5152/TJAR.2019.65391
pii: tard-47-5-407
pmc: PMC6756315
doi:
Types de publication
Journal Article
Langues
eng
Pagination
407-413Informations de copyright
© Copyright 2019 by Turkish Anaesthesiology and Intensive Care Society.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
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