Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer.

Cell Line, Tumor Curcumin / pharmacology DNA Damage Female Homologous Recombination Humans Triple Negative Breast Neoplasms / drug therapy

Journal

Nutrition and cancer
ISSN: 1532-7914
Titre abrégé: Nutr Cancer
Pays: United States
ID NLM: 7905040

Informations de publication

Date de publication:
2020
Historique:
pubmed: 2 10 2019
medline: 19 8 2021
entrez: 2 10 2019
Statut: ppublish

Résumé

Curcumin has a therapeutic potential activity through modulation of different signaling pathways in various types of cancer. However, the relationship between the efficacy of curcumin and the homologous recombination (HR) mechanism which plays important roles in the repair of double strand DNA (dsDNA) breaks remains uncertain. Herein, we explored curcumin-dependent dsDNA breaks and the association of curcumin with HR mechanism in triple negative breast cancer (TNBC). The cytotoxic and therapeutic activity of curcumin on HCC1937 (

Identifiants

DOI: 10.1080/01635581.2019.1670216 PMID: 31573354
pubmed: 31573354
doi: 10.1080/01635581.2019.1670216
doi:

Substances chimiques

Curcumin IT942ZTH98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1057-1066

Auteurs

Gamze Guney Eskiler (G)

Faculty of Medicine, Department of Medical Biology, Sakarya University, Sakarya, Turkey.

Elvan Sahin (E)

Faculty of Medicine, Department of Histology and Embryology, Sakarya University, Sakarya, Turkey.

Asuman Deveci Ozkan (A)

Faculty of Medicine, Department of Medical Biology, Sakarya University, Sakarya, Turkey.
ORCID: 0000-0002-3248-4279

Ozlem Tugce Cilingir Kaya (OT)

Faculty of Medicine, Department of Histology and Embryology, Marmara University, Istanbul, Turkey.
ORCID: 0000-0002-2591-9174

Suleyman Kaleli (S)

Faculty of Medicine, Department of Medical Biology, Sakarya University, Sakarya, Turkey.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Curcumin induces DNA damage by mediating...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Curcumin induces DNA damage by mediating...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Curcumin induces DNA damage by mediating...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Curcumin induces DNA damage by mediating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Curcumin induces DNA damage by mediating...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Curcumin induces DNA damage by mediating...