Frailty, hospital use and mortality in the older population: findings from the Newcastle 85+ study.


Journal

Age and ageing
ISSN: 1468-2834
Titre abrégé: Age Ageing
Pays: England
ID NLM: 0375655

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 30 08 2018
revised: 11 03 2019
pubmed: 2 10 2019
medline: 1 9 2020
entrez: 2 10 2019
Statut: ppublish

Résumé

Frailty is a significant determinant of health care utilisation and associated costs, both of which also increase with proximity to death. What is not known is how the relationships between frailty, proximity to death, hospital use and costs develop in a population aged 85 years and over. This study used data from a prospective observational cohort, the Newcastle 85+ Study, linked with hospital episode statistics and death registrations. Using the Rockwood frailty index (cut off <0.25), we analysed the relationship between frailty and mortality, proximity to death, hospital use and hospital costs over 2, 5 and 7 years using descriptive statistics, Kaplan-Meier survival curves, Cox's proportional hazards and negative binomial regression models. Baseline frailty was associated with a more than two-fold increased risk of mortality after 7 years, compared to people who were non-frail. Participants classified as frail spent more time in hospital over 7 years than the non-frail, but this difference declined over time. Baseline frailty was not associated with increased time spent in hospital during the last 90 days of life. Evidence continues to accrue on the impact of frailty on emergency health care use. Hospital and community services need to adapt to meet the challenge of introducing new proactive and preventative approaches, designed to achieve benefits in clinical and/or cost effectiveness of frailty management.

Sections du résumé

BACKGROUND
Frailty is a significant determinant of health care utilisation and associated costs, both of which also increase with proximity to death. What is not known is how the relationships between frailty, proximity to death, hospital use and costs develop in a population aged 85 years and over.
METHODS
This study used data from a prospective observational cohort, the Newcastle 85+ Study, linked with hospital episode statistics and death registrations. Using the Rockwood frailty index (cut off <0.25), we analysed the relationship between frailty and mortality, proximity to death, hospital use and hospital costs over 2, 5 and 7 years using descriptive statistics, Kaplan-Meier survival curves, Cox's proportional hazards and negative binomial regression models.
RESULTS
Baseline frailty was associated with a more than two-fold increased risk of mortality after 7 years, compared to people who were non-frail. Participants classified as frail spent more time in hospital over 7 years than the non-frail, but this difference declined over time. Baseline frailty was not associated with increased time spent in hospital during the last 90 days of life.
CONCLUSION
Evidence continues to accrue on the impact of frailty on emergency health care use. Hospital and community services need to adapt to meet the challenge of introducing new proactive and preventative approaches, designed to achieve benefits in clinical and/or cost effectiveness of frailty management.

Identifiants

pubmed: 31573609
pii: 5579860
doi: 10.1093/ageing/afz094
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

797-802

Subventions

Organisme : Medical Research Council
ID : G0500997
Pays : United Kingdom
Organisme : Department of Health
ID : HS&DR/12/5003/02
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J50001X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Auteurs

Eilis Keeble (E)

Nuffield Trust, London, UK.

Stuart G Parker (SG)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Sandeepa Arora (S)

Nuffield Trust, London, UK.

Jenny Neuburger (J)

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Rachel Duncan (R)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Andrew Kingston (A)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Barbara Hanratty (B)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Carol Jagger (C)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Louise Robinson (L)

Newcastle University, Institute for Health and Society, Newcastle Institute for Ageing, Newcastle upon Tyne, UK.

Tom Kirkwood (T)

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.

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