Understanding the binding interaction between methotrexate and human alpha-2-macroglobulin: Multi-spectroscopic and computational investigation.

Computer Simulation Humans Methotrexate / metabolism Molecular Docking Simulation Molecular Dynamics Simulation Pregnancy-Associated alpha 2-Macroglobulins / metabolism Protein Binding Spectrum Analysis / methods
Alpha-2-macroglobulin Anticancer drug Antiproteinase Methotrexate Reactive oxygen species

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
30 10 2019
Historique:
received: 11 07 2019
revised: 21 09 2019
accepted: 24 09 2019
pubmed: 2 10 2019
medline: 9 4 2020
entrez: 2 10 2019
Statut: ppublish

Résumé

Methotrexate (MTX) is advised in the treatment of solid tumours, hematologic malignancies and autoimmune disorders. On reaching the circulation, 60% of MTX is bound to the proteins present in serum. Alpha-2-macroglobulin (α

Identifiants

DOI: 10.1016/j.abb.2019.108118 PMID: 31574256
pubmed: 31574256
pii: S0003-9861(19)30541-7
doi: 10.1016/j.abb.2019.108118
pii:
doi:

Substances chimiques

Pregnancy-Associated alpha 2-Macroglobulins 0
Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108118

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Mohammad Khalid Zia (MK)

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India.

Tooba Siddiqui (T)

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India.

Syed Saqib Ali (SS)

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India.

Haseeb Ahsan (H)

Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, 110025, India.

Fahim Halim Khan (FH)

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India. Electronic address: fahimhkhan@rediffmail.com.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Understanding the binding interaction between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Understanding the binding interaction between...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Aminoptérine › Méthotrexate › Understanding the binding interaction between...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Understanding the binding interaction between...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Understanding the binding interaction between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › alpha 2-Macroglobulines associées à la grossesse › Understanding the binding interaction between...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Understanding the binding interaction between...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Understanding the binding interaction between...