High Pyridine Generation in Ceftazidime-Icodextrin Admixtures Used to Treat Peritoneal Dialysis-associated Peritonitis.

Anti-Bacterial Agents / chemistry Ceftazidime / chemistry Dialysis Solutions / chemistry Drug Combinations Drug Stability Icodextrin / chemistry Peritoneal Dialysis / adverse effects Peritonitis / drug therapy Pyridines / chemistry
ceftazidime peritoneal dialysis peritonitis pyridine stability toxicity

Journal

Clinical therapeutics
ISSN: 1879-114X
Titre abrégé: Clin Ther
Pays: United States
ID NLM: 7706726

Informations de publication

Date de publication:
11 2019
Historique:
received: 08 07 2019
revised: 12 08 2019
accepted: 29 08 2019
pubmed: 3 10 2019
medline: 7 7 2020
entrez: 3 10 2019
Statut: ppublish

Résumé

To investigate the amount of pyridine generated from degradation of ceftazidime in icodextrin peritoneal dialysis (PD) solutions. PD solutions that contained 1 and 1.5 g of ceftazidime were stored at 25 °C for 12 hours and then at 37 °C for 14 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentrations of ceftazidime and pyridine. The amount of pyridine generated was >225% and 400% of its maximum recommended daily exposure in the 1- and 1.5-g ceftazidime-PD admixtures, respectively. Until these results are confirmed with appropriate in vivo studies, intermittent intraperitoneal dosing of ceftazidime admixed with icodextrin should be used with caution and appropriate clinical monitoring or a suitable alternative antibiotic should be used.

Identifiants

DOI: 10.1016/j.clinthera.2019.08.021 PMID: 31575441
pubmed: 31575441
pii: S0149-2918(19)30474-6
doi: 10.1016/j.clinthera.2019.08.021
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Dialysis Solutions 0
Drug Combinations 0
Pyridines 0
Icodextrin 2NX48Z0A9G
Ceftazidime 9M416Z9QNR
pyridine NH9L3PP67S

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2446-2451

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Harpreet Kaur (H)

Department of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.

Harmanjeet Harmanjeet (H)

Department of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.

Troy Wanandy (T)

Department of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia; Department of Pharmacy and Jack Jumper Allergy Program, Royal Hobart Hospital, Hobart, Tasmania, Australia.

Ronald L Castelino (RL)

Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia; Peritoneal Dialysis Unit, Regional Dialysis Centre, Blacktown Hospital, Blacktown, New South Wales, Australia.

Kamal Sud (K)

Peritoneal Dialysis Unit, Regional Dialysis Centre, Blacktown Hospital, Blacktown, New South Wales, Australia; Department of Renal Medicine, Nepean Hospital and Nepean Clinical School, The University of Sydney, Kingswood, New South Wales, Australia.

Matthew D Jose (MD)

Department of Nephrology, Royal Hobart Hospital, Hobart, Tasmania, Australia.

Gregory M Peterson (GM)

Department of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.

Rahul P Patel (RP)

Department of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: rahul.patel@utas.edu.au.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › High Pyridine Generation in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfaloridine › Ceftazidime › High Pyridine Generation in...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solutions pharmaceutiques › Solutions de dialyse › High Pyridine Generation in...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › High Pyridine Generation in...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › High Pyridine Generation in...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Icodextrine › High Pyridine Generation in...
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › Dialyse péritonéale › High Pyridine Generation in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du péritoine › Péritonite › High Pyridine Generation in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › High Pyridine Generation in...