A Model-Based Method for Assessment of Salivary Gland and Planning Target Volume Dosimetry in Volumetric-Modulated Arc Therapy Planning on Head-and-Neck Cancer.
Generalized equivalent uniform dose optimization
head-and-neck cancer
radiotherapy
salivary gland sparing
volumetric-modulated arc therapy plan
Journal
Journal of medical physics
ISSN: 0971-6203
Titre abrégé: J Med Phys
Pays: India
ID NLM: 9441104
Informations de publication
Date de publication:
Historique:
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
3
10
2019
Statut:
ppublish
Résumé
This study examined the relationship of achievable mean dose and percent volumetric overlap of salivary gland with the planning target volume (PTV) in volumetric-modulated arc therapy (VMAT) plan in radiotherapy for a patient with head-and-neck cancer. The aim was to develop a model to predict the viability of planning objectives for both PTV coverage and organs-at-risk (OAR) sparing based on overlap volumes between PTVs and OARs, before the planning process. Forty patients with head-and-neck cancer were selected for this retrospective plan analysis. The patients were treated using 6 MV photons with 2-arc VMAT plan in prescriptions with simultaneous integrated boost in dose of 70 Gy, 63 Gy, and 58.1 Gy to primary tumor sites, high-risk nodal regions, and low-risk nodal regions, respectively, over 35 fractions. A VMAT plan was generated using Varian Eclipse (V13.6), in optimization with biological-based generalized equivalent uniform dose (gEUD) objective for OARs and targets. Target dose coverage (
Identifiants
pubmed: 31576068
doi: 10.4103/jmp.JMP_19_19
pii: JMP-44-201
pmc: PMC6764180
doi:
Types de publication
Journal Article
Langues
eng
Pagination
201-206Informations de copyright
Copyright: © 2019 Journal of Medical Physics.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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