Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB.
BDNF
TrkB
hippocampus
intensive exercise
prefrontal cortex
sleep deprivation
spatial memory
Journal
Nature and science of sleep
ISSN: 1179-1608
Titre abrégé: Nat Sci Sleep
Pays: New Zealand
ID NLM: 101537767
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
03
2019
accepted:
29
07
2019
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
3
10
2019
Statut:
epublish
Résumé
Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount. The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC). Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting. After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels. The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.
Sections du résumé
BACKGROUND
BACKGROUND
Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.
PURPOSE
OBJECTIVE
The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).
MATERIAL AND METHODS
METHODS
Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.
RESULTS
RESULTS
After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.
CONCLUSION
CONCLUSIONS
The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.
Identifiants
pubmed: 31576186
doi: 10.2147/NSS.S207339
pii: 207339
pmc: PMC6767759
doi:
Types de publication
Journal Article
Langues
eng
Pagination
179-188Informations de copyright
© 2019 Mahboubi et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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