Purinergic signaling in hepatic disease.
Ectonucleotidases
Fibrosis
Inflammation
Liver
Purinergic receptors
Journal
Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
25
05
2019
accepted:
02
09
2019
pubmed:
3
10
2019
medline:
9
9
2020
entrez:
3
10
2019
Statut:
ppublish
Résumé
Extracellular purines (ATP and adenosine) are ubiquitous intercellular messengers. During tissular damage, they function as damage-associated molecular patterns (DAMPs). In this context, purines announce tissue alterations to initiate a reparative response that involve the formation of the inflammasome complex and the recruitment of specialized cells of the immune system. The present review focuses on the role of the purinergic system in liver damage, mainly during the onset and development of fibrosis. After hepatocellular injury, extracellular ATP promotes a signaling cascade that ameliorates tissue alterations to restore the hepatic function. However, if cellular damage becomes chronic, ATP orchestrates an aberrant reparative process that results in severe liver diseases such as fibrosis and cirrhosis. ATP and adenosine, their receptors, and extracellular ectonucleotidases are mediators of unique processes that will be reviewed in detail.
Identifiants
pubmed: 31576486
doi: 10.1007/s11302-019-09680-3
pii: 10.1007/s11302-019-09680-3
pmc: PMC6923300
doi:
Substances chimiques
Purines
0
Receptors, Purinergic
0
Adenosine Triphosphate
8L70Q75FXE
Adenosine
K72T3FS567
purine
W60KTZ3IZY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-489Références
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