Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans.
Alternative splicing
Cancer disparities
Drug resistance
Prostate cancer
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
8
10
2019
Statut:
ppublish
Résumé
Alternative splicing, the process of removing introns and joining exons of pre-mRNA, is critical for growth, development, tissue homeostasis, and species diversity. Dysregulation of alternative splicing can initiate and drive disease. Aberrant alternative splicing has been shown to promote the "hallmarks of cancer" in both hematological and solid cancers. Of interest, recent work has focused on the role of alternative splicing in prostate cancer and prostate cancer health disparities. We will provide a review of prostate cancer health disparities involving the African American population, alternative RNA splicing, and alternative splicing in prostate cancer. Lastly, we will summarize our work on differential alternative splicing in prostate cancer disparities and its implications for disparate health outcomes and therapeutic targets.
Identifiants
pubmed: 31576545
doi: 10.1007/978-3-030-22254-3_10
pmc: PMC6777849
mid: NIHMS1010139
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-139Subventions
Organisme : NCI NIH HHS
ID : R01 CA204806
Pays : United States
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