Molecular foundations of chiropractic therapy.
Journal
Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064
Informations de publication
Date de publication:
30 09 2019
30 09 2019
Historique:
received:
06
08
2019
accepted:
06
08
2019
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
24
10
2020
Statut:
epublish
Résumé
Alternative medicine is a broad term used to encompass different therapies, including chiropractic. Chiropractic was called "a science of healing without drugs" by its founder, David Daniel Palmer. It is based on the idea that the body has a powerful self-healing ability and that there is a relationship between body structure and function that affects health. In particular, chiropractic assumes that the nervous system controls the human body through nerves branching from the vertebral column and spinal cord. Researchers do not fully understand how chiropractic therapies affect pain, but chiropractic is widely used today to treat chronic pain, such as back pain. Different studies with animal models have demonstrated that chiropractic therapies mediate neuroplasticity, specifically through modulation of neurotrophins. No studies have yet been published on interaction between neurotrophin gene polymorphisms and chiropractic treatment. We searched PubMed with the following keywords: chiropractic, neuroplasticity, neurotrophin gene polymorphism for a panorama of on the molecular mechanisms of chiropractic therapy. From the material collected, we identified a set of genes and some functional polymorphisms that could be correlated with better response to chiropractic therapy. Further association studies will be necessary to confirm hypotheses of a correlation between single nucleotide polymorphisms in specific genes and better response to chiropractic therapy.
Sections du résumé
BACKGROUND AND AIM
Alternative medicine is a broad term used to encompass different therapies, including chiropractic. Chiropractic was called "a science of healing without drugs" by its founder, David Daniel Palmer. It is based on the idea that the body has a powerful self-healing ability and that there is a relationship between body structure and function that affects health. In particular, chiropractic assumes that the nervous system controls the human body through nerves branching from the vertebral column and spinal cord. Researchers do not fully understand how chiropractic therapies affect pain, but chiropractic is widely used today to treat chronic pain, such as back pain. Different studies with animal models have demonstrated that chiropractic therapies mediate neuroplasticity, specifically through modulation of neurotrophins. No studies have yet been published on interaction between neurotrophin gene polymorphisms and chiropractic treatment.
METHODS
We searched PubMed with the following keywords: chiropractic, neuroplasticity, neurotrophin gene polymorphism for a panorama of on the molecular mechanisms of chiropractic therapy.
RESULTS
From the material collected, we identified a set of genes and some functional polymorphisms that could be correlated with better response to chiropractic therapy.
CONCLUSIONS
Further association studies will be necessary to confirm hypotheses of a correlation between single nucleotide polymorphisms in specific genes and better response to chiropractic therapy.
Identifiants
pubmed: 31577263
doi: 10.23750/abm.v90i10-S.8768
pmc: PMC7233649
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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