Can Increased Metabolic Status be a Grading Tool for Oral Squamous Cell Carcinoma? A Glucose Transporter 1 Immunoexpression Study.
Glucose transporter 1
grading
immunoexpression
metabolic status
oral squamous cell carcinoma
Journal
Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society
ISSN: 1117-6806
Titre abrégé: Niger J Surg
Pays: India
ID NLM: 101189891
Informations de publication
Date de publication:
Historique:
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
4
10
2019
Statut:
ppublish
Résumé
Glucose transporter-1 (GLUT-1) is a GLUT protein whose expression is upregulated in malignant cells where enhanced uptake of glucose is observed. The aim of this study is to evaluate the expression of GLUT-1 protein in oral squamous cell carcinoma (OSCC) tissue sections using immunohistochemistry and to describe the relationship between increased metabolic status and the grades of OSCC. This is cross-sectional study with 76 formalin-fixed paraffin-embedded tissue blocks of OSCC, obtained from the archives of the department. All the cases were scored using Bryne's grading system by three oral pathologists independently. The tissue sections were then stained using immunohistochemistry with anti-GLUT-1 rabbit monoclonal antibody. Staining intensity and localization of positively stained slides were evaluated. Overall, a significant correlation between Bryne's histopathological grading system for OSCC and GLUT-1 immunohistochemical expression was observed. Thus, high GLUT-1 expressions are observed with increasing grades of OSCC. This study shows that a significant positive correlation exists between GLUT-1 immunoexpression and histological grading of OSCC. Thus, GLUT-1 expression can be used as a diagnostic adjunct and prognostic marker for OSCC patients.
Sections du résumé
BACKGROUND
BACKGROUND
Glucose transporter-1 (GLUT-1) is a GLUT protein whose expression is upregulated in malignant cells where enhanced uptake of glucose is observed.
AIM
OBJECTIVE
The aim of this study is to evaluate the expression of GLUT-1 protein in oral squamous cell carcinoma (OSCC) tissue sections using immunohistochemistry and to describe the relationship between increased metabolic status and the grades of OSCC.
MATERIALS AND METHODS
METHODS
This is cross-sectional study with 76 formalin-fixed paraffin-embedded tissue blocks of OSCC, obtained from the archives of the department. All the cases were scored using Bryne's grading system by three oral pathologists independently. The tissue sections were then stained using immunohistochemistry with anti-GLUT-1 rabbit monoclonal antibody.
RESULTS
RESULTS
Staining intensity and localization of positively stained slides were evaluated. Overall, a significant correlation between Bryne's histopathological grading system for OSCC and GLUT-1 immunohistochemical expression was observed. Thus, high GLUT-1 expressions are observed with increasing grades of OSCC.
CONCLUSION
CONCLUSIONS
This study shows that a significant positive correlation exists between GLUT-1 immunoexpression and histological grading of OSCC. Thus, GLUT-1 expression can be used as a diagnostic adjunct and prognostic marker for OSCC patients.
Identifiants
pubmed: 31579378
doi: 10.4103/njs.NJS_17_18
pii: NJS-25-203
pmc: PMC6771186
doi:
Types de publication
Journal Article
Langues
eng
Pagination
203-207Informations de copyright
Copyright: © 2019 Nigerian Journal of Surgery.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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