Ginsenoside Rh1 inhibits colorectal cancer cell migration and invasion
colorectal cancer
ginsenoside Rh1
invasion
migration
tumor growth
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
30
09
2018
accepted:
05
06
2019
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
4
10
2019
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is the third leading cause of cancer-associated mortality worldwide. Ginsenoside Rh1 (Rh1) is a traditional medicine monomer with antitumor activity; however, the effects of Rh1 in CRC remain to be determined. In the present study, SW620 cells were treated with different concentrations of Rh1. Cell Counting Kit-8, wound healing and Transwell assays were performed to measure cell viability and proliferation, migration and invasion, respectively. Subsequently, the mRNA expression levels of matrix metallopeptidase (MMP)1, MMP3 and tissue inhibitor of metalloproteinases 3 (TIMP3) were detected by reverse transcription-quantitative PCR analysis. In addition, the protein expression levels of MMP1, MMP3, TIMP3, and total or phosphorylated (p-)ERK1/2, P38, JNK were detected by western blotting. Furthermore, tumor growth was examined in a nude mouse xenograft model. The results of the present study indicated that Rh1 was not toxic to CRC cells at various concentrations (0, 50 or 100 µM) and treatment durations (24 or 48 h). However, cell proliferation was suppressed by Rh1 in a dose-dependent manner. Rh1 (100 µM) significantly inhibited cell migration and invasion
Identifiants
pubmed: 31579419
doi: 10.3892/ol.2019.10742
pii: OL-0-0-10742
pmc: PMC6757309
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4160-4166Informations de copyright
Copyright: © Lyu et al.
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