Immunogenicity and protection effects of cationic liposome containing imiquimod adjuvant on leishmaniasis in BALB/c mice.

Cationic liposome Leishmania major Imiquimod Immune response Vaccine

Journal

Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966

Informations de publication

Date de publication:
Aug 2019
Historique:
entrez: 4 10 2019
pubmed: 4 10 2019
medline: 4 10 2019
Statut: ppublish

Résumé

Protection against leishmaniasis, in the murine model, is dependent on developing a potent CD4 Liposomes were provided applying the lipid film procedure. BALB/C mice were subcutaneously immunized, three times with 2-week intervals, with various formulations. Assessment of lesion development and parasite burden in the foot and spleen after challenge with The mice immunized with Liposome DOTAP+imiquimod+SLA showed smaller footpad swelling which was meaningfully different ( The results of this study show that liposome DOTAP+SLA+imiquimod formulation generates a cellular immune response that is protective against challenge against

Identifiants

DOI: 10.22038/ijbms.2019.35739.8515 PMID: 31579449 PMC: PMC6760488
pubmed: 31579449
doi: 10.22038/ijbms.2019.35739.8515
pmc: PMC6760488
doi:

Types de publication

Journal Article

Langues

eng

Pagination

922-931

Déclaration de conflit d'intérêts

The authors declare that there are no conflicts of interest.

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Auteurs

Ahmad Mehravaran (A)

Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Maryam Rezaei Nasab (M)

Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Hadi Mirahmadi (H)

Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Iraj Sharifi (I)

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Ebrahim Alijani (E)

Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Amin Reza Nikpoor (AR)

Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Javad Akhtari (J)

Immunogenetics Research Center, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Mansure Hojatizade (M)

Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Classifications MeSH