Circulating B Cells With Memory and Antibody-Secreting Phenotypes Are Detectable in Pediatric Kidney Transplant Recipients Before the Development of Antibody-Mediated Rejection.
Journal
Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
10
05
2019
accepted:
16
05
2019
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
4
10
2019
Statut:
epublish
Résumé
Development of anti-human leukocyte antigen donor-specific antibodies (DSAs) is associated with antibody-mediated rejection (AMR) and reduced allograft survival in kidney transplant recipients. Whether changes in circulating lymphocytes anticipate DSA or AMR development is unclear. We used time-of-flight mass cytometry to analyze prospectively collected peripheral blood mononuclear cells (PBMC) from pediatric kidney transplant recipients who developed DSA (DSA-positive recipients [DSA DSA Despite the small sample size, our comprehensive phenotypic analyses show that circulating B cells with memory and antibody-secreting phenotypes are present at DSA onset, >1 year before biopsy-proven AMR in pediatric kidney transplant recipients.
Identifiants
pubmed: 31579809
doi: 10.1097/TXD.0000000000000914
pmc: PMC6739044
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e481Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK007757
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
World J Transplant. 2013 Dec 24;3(4):113-8
pubmed: 24392315
Transplantation. 2016 Feb;100(2):391-9
pubmed: 26555944
Transplant Rev (Orlando). 2015 Apr;29(2):78-84
pubmed: 25687818
Am J Transplant. 2018 Jan;18 Suppl 3:3-17
pubmed: 29292861
Transplant Proc. 2017 Nov;49(9):2031-2035
pubmed: 29149956
Transplantation. 2011 Feb 15;91(3):342-7
pubmed: 21116220
Am J Transplant. 2012 May;12(5):1157-67
pubmed: 22429309
Eur J Immunol. 1994 May;24(5):1218-22
pubmed: 8181532
Methods Mol Biol. 2013;1034:41-70
pubmed: 23775730
Am J Transplant. 2016 Jul;16(7):2106-16
pubmed: 26725780
Cytometry B Clin Cytom. 2018 Sep;94(5):588-601
pubmed: 28865188
Nat Immunol. 2001 Sep;2(9):876-81
pubmed: 11526405
Am J Transplant. 2004 Mar;4(3):378-83
pubmed: 14961990
Kidney Int. 2015 Oct;88(4):874-87
pubmed: 26176829
Clin Exp Immunol. 2015 May;180(2):329-40
pubmed: 25557528
Nat Rev Immunol. 2015 Mar;15(3):160-71
pubmed: 25698678
J Am Soc Nephrol. 2016 Feb;27(2):615-25
pubmed: 26047793
J Immunol. 1990 Oct 15;145(8):2390-6
pubmed: 1976692
Am J Transplant. 2019 Feb;19(2):368-380
pubmed: 30085394
Hum Immunol. 2011 Oct;72(10):849-58
pubmed: 21791230
PLoS One. 2016 Apr 14;11(4):e0153355
pubmed: 27078882
Pediatr Transplant. 2012 Feb;16(1):12-7
pubmed: 22093755
Transplantation. 2017 Sep;101(9):2165-2174
pubmed: 27653301
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
Am J Transplant. 2011 Mar;11(3):450-62
pubmed: 20973913
Transplantation. 2003 Apr 15;75(7):1034-40
pubmed: 12698094
Immunity. 2014 Dec 18;41(6):1040-51
pubmed: 25484301
J Immunol. 1986 Jan;136(1):83-92
pubmed: 3484392
Am J Transplant. 2011 Jun;11(6):1226-35
pubmed: 21564524
Clin J Am Soc Nephrol. 2018 Jan 6;13(1):182-192
pubmed: 28446536
Cell. 2017 May 4;169(4):750-765.e17
pubmed: 28475900
Transplantation. 2010 Jul 15;90(1):68-74
pubmed: 20463643
Am J Transplant. 2017 Jun;17(6):1490-1501
pubmed: 27888555
Curr Opin Immunol. 1999 Apr;11(2):172-9
pubmed: 10322151
Cell. 2015 Jul 2;162(1):184-97
pubmed: 26095251
Pediatrics. 1976 Aug;58(2):259-63
pubmed: 951142
Kidney Int. 2010 Feb;77(4):299-311
pubmed: 19847156
Science. 2013 Sep 13;341(6151):1205-11
pubmed: 24031013
Transpl Int. 2014 Jul;27(7):667-73
pubmed: 24629017
N Engl J Med. 2013 Sep 26;369(13):1215-26
pubmed: 24066742
Immunol Res. 2000;21(1):23-30
pubmed: 10803880
J Immunol Methods. 2004 Mar;286(1-2):111-22
pubmed: 15087226
Transpl Int. 2013 Feb;26(2):121-30
pubmed: 23145861
Blood. 2003 Sep 15;102(6):2146-55
pubmed: 12763926
Transplantation. 2014 Sep 27;98(6):625-31
pubmed: 25058376
Pediatrics. 2014 Apr;133(4):594-601
pubmed: 24616363
PLoS One. 2018 Nov 14;13(11):e0207434
pubmed: 30427941
Pediatr Transplant. 2012 Sep;16(6):613-8
pubmed: 22694118
Transplant Proc. 2018 Dec;50(10):3460-3466
pubmed: 30577221
Am J Transplant. 2019 Jan;19(1):89-97
pubmed: 29947147
Am J Transplant. 2018 Jan;18 Suppl 1:18-113
pubmed: 29292608
Transplantation. 2013 Jan 27;95(2):341-6
pubmed: 23197178
Am J Transplant. 2009 Nov;9 Suppl 3:S1-155
pubmed: 19845597
Lancet. 2011 Oct 15;378(9800):1428-37
pubmed: 22000139
Kidney Int. 2014 Jun;85(6):1267-8
pubmed: 24875549
Transplantation. 2011 Jan 27;91(2):183-90
pubmed: 21079553
Transplantation. 2015 Jan;99(1):21-8
pubmed: 25525921
Transplantation. 2013 May 15;95(9):1113-9
pubmed: 23514959
J Am Soc Nephrol. 2015 Jul;26(7):1721-31
pubmed: 25556173
Immunity. 1995 Mar;2(3):239-48
pubmed: 7535180
J Transplant. 2012;2012:302539
pubmed: 22970343
Transplantation. 2016 Feb;100(2):264-5
pubmed: 26479286
J Allergy Clin Immunol. 2013 Apr;131(4):1204-12
pubmed: 23453135
Trends Mol Med. 2015 May;21(5):319-29
pubmed: 25801125
J Am Soc Nephrol. 2015 Feb;26(2):457-67
pubmed: 25125383
Nat Rev Immunol. 2016 Oct;16(10):612-25
pubmed: 27573485
Blood. 2005 Apr 15;105(8):3042-50
pubmed: 15613544
Vaccine. 2009 Dec 10;28(1):179-86
pubmed: 19799844
Am J Transplant. 2016 Jan;16 Suppl 2:11-46
pubmed: 26755262
Am J Transplant. 2014 Feb;14(2):272-83
pubmed: 24472190
J Am Soc Nephrol. 2010 Aug;21(8):1398-406
pubmed: 20634297