Ruminococcin C, a promising antibiotic produced by a human gut symbiont.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
13
02
2019
accepted:
27
08
2019
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
19
5
2020
Statut:
epublish
Résumé
A major public health challenge today is the resurgence of microbial infections caused by multidrug-resistant strains. Consequently, novel antimicrobial molecules are actively sought for development. In this context, the human gut microbiome is an under-explored potential trove of valuable natural molecules, such as the ribosomally-synthesized and post-translationally modified peptides (RiPPs). The biological activity of the sactipeptide subclass of RiPPs remains under-characterized. Here, we characterize an antimicrobial sactipeptide, Ruminococcin C1, purified from the caecal contents of rats mono-associated with
Identifiants
pubmed: 31579822
doi: 10.1126/sciadv.aaw9969
pii: aaw9969
pmc: PMC6760926
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw9969Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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