Site-specific pharmaco-laser therapy: A novel treatment modality for refractory port wine stains.
antifibrinolytics
hemodynamics
liposomes
mild hyperthermia
photosensitizer
primary and secondary hemostasis
procoagulants
steric stabilization
thermal coagulum
tranexamic acid
Journal
Journal of clinical and translational research
ISSN: 2424-810X
Titre abrégé: J Clin Transl Res
Pays: Singapore
ID NLM: 101667205
Informations de publication
Date de publication:
08 Sep 2019
08 Sep 2019
Historique:
received:
22
02
2019
revised:
29
03
2019
revised:
18
04
2019
accepted:
18
04
2019
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
4
10
2019
Statut:
epublish
Résumé
Despite extensive efforts to optimize laser therapy, i.e., the current gold standard treatment, a majority of port wine stain (PWS) patients responds suboptimally to laser therapy. This paper describes the niceties of a novel PWS treatment modality termed site-specific pharmaco-laser therapy (SSPLT). In contrast to the classic approach of enhancing the extent of intravascular photocoagulation (the photothermal response), SSPLT focuses on optimization of post-irradiation thrombus formation (i.e., the hemodynamic response) by combining conventional laser therapy with the administration of thermosensitive drug delivery systems that encapsulate prothrombotic and antifibrinolytic drugs. The aim of SSPLT is to instill complete lumenal occlusion in target vessels, which has been linked to optimal PWS blanching. The current treatment options for PWS patients are limited in efficacy. Novel therapeutic modalities are needed to more effectively treat patients with recalcitrant PWSs. SSPLT is an experimental-stage treatment modality that could serve as an adjuvant to pulsed dye laser therapy for a selected group of patients whose PWS is ill-responsive to standard treatment. The expected clinical result of SSPLT is improved lesional blanching.
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-24Informations de copyright
Copyright © 2019, Whioce Publishing Pte. Ltd.
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