Pharmacokinetic profiles of meloxicam after single IV and PO administration in Bilgorajska geese.
HPLC
analgesic
geese
pharmacokinetics
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
20
05
2019
revised:
20
08
2019
accepted:
30
08
2019
pubmed:
4
10
2019
medline:
21
10
2020
entrez:
4
10
2019
Statut:
ppublish
Résumé
The purpose of this study was two-fold: I) to determine the pharmacokinetic profile of meloxicam (MLX) in geese after intravenous (IV) and oral (PO) administration and II) to assess tissue residues in muscle, heart, liver, lung, and kidney. Ten clinically normal female Bilgorajska geese were divided into two groups (treated, n = 8; control, n = 2). Group 1 underwent a 3-phase parallel study with a 1-week washout period. In phase I, animals received MLX (0.5 mg/kg) by IV administration; the blood was collected up to 48 hr. In phases II and III geese were treated orally at the same dosage for the collection of blood and tissue samples, respectively. Group 2 served as control. After the extraction procedure, a validated HPLC method with UV detection was used for plasma and organ analysis. The plasma concentrations were quantifiable up to 24 hr after both the administrations. The elimination phase of MLX from plasma was similar in both the administration groups. The clearance was slow (0.00975 L/hr*Kg), the volume of distribution small (0.0487 L/kg), and the IV half-life was 5.06 ± 2.32 hr. The average absolute PO bioavailability was 64.2 ± 24.0%. Residues of MLX were lower than the LOQ (0.1 µg/kg) in any tested tissue and at any collection time. The dosage used in this study achieved the plasma concentration, which provides analgesia in Hispaniolan Amazon parrots for 5 out of 24 hr after PO administration. MLX tissue concentrations were below the LOD of the assay in tissue (0.03 µg/ml). A more sensitive technique might be necessary to determine likely residue concentrations in tissue.
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Meloxicam
VG2QF83CGL
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-32Subventions
Organisme : Ex 60% University of Pisa 2017
Informations de copyright
© 2019 John Wiley & Sons Ltd.
Références
Anonymous (2000). EMEA/MRL/635/99-FINAL Committee for veterinary medicinal products. Meloxicam (extension to pigs). Retrieved from: https://www.ema.europa.eu/en/documents/mrl-report/meloxicam-extension-pigs-summary-report-5-committee-veterinary-medicinal-products_en.pdf
Anonymous (2012). Guideline on Bioanalytical Method Validation. EMEA/ CHMP/EWP/192217/2009 Rev. 1 Corr.*. Committee for Medicinal Products for Human Use (CHMP). Retrieved from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf
Baert, K., & De Backer, P. (2003). Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 134, 25-33. https://doi.org/10.1016/S1532-0456(02)00184-9
Bisht, P., Ahmad, A. H., Mishra, A., Jaiswal, M., & Kumar, N. (2019). Pharmacokinetic study of meloxicam in poultry following multiple doses by intramuscular administration. The Pharma Innovation Journal, 8(2), 189-191.
Boothe, D. M. (2001). The analgesic, antipyretic, anti-inflammatory drugs. In H. R. Adams (Ed.), Veterinary pharmacology and therapeutics, 8th ed. (pp. 433-451). Ames, IA: Iowa State University Press.
De Vito, V., Łebkowska-Wieruszewska, B., Lavy, E., Lisowski, A., Owen, H., & Giorgi, M. (2018). Pharmacokinetics of meloxicam in lactating goats (Capra hircus) and its quantification in milk after a single intravenous and intramuscular injection. Small Ruminant Research, 160, 38-43. https://doi.org/10.1016/j.smallrumres.2018.01.001
Degernes, L. A., Lynch, P. S., & Shivaprasad, H. L. (2011). Degenerative joint disease in captive waterfowl. Avian Pathology, 40(1), 103-110. https://doi.org/10.1080/03079457.2010.541421
Gates, B. J., Nguyen, T. T., Stetter, S. M., & Davies, N. M. (2005). Meloxicam: A reappraisal of pharmacokinetics, efficacy and safety. Expert Opinion in Pharmacotherapy, 6, 2117-2140. https://doi.org/10.1517/14656566.6.12.2117
Hörl, W. H. (2010). Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals (Basel), 3(7), 2291-2321. https://doi.org/10.3390/ph3072291
Jayakumar, K., Mohan, K., Narayana Swamy, H. D., Shridhar, N. B., & Bayer, M. D. (2010). Study of nephrotoxic potential of acetaminophen in birds. Toxicology International, 17(2), 86-89. https://doi.org/10.4103/0971-6580.72677
Kimble, B., Black, L. A., Li, K. M., Valtchev, P., Gilchrist, S., Gillett, A., … Govendir, M. (2013). Pharmacokinetics of meloxicam in koalas (Phascolarctos cinereus) after intravenous, subcutaneous and oral administration. Journal of Veterinary Pharmacology and Therapeutics, 36, 486-493. https://doi.org/10.1111/jvp.12038
Kozák, J., Gara, I., & Kawada, T. (2010). Production and welfare aspects of goose down and feather harvesting. World's Poultry Science Journal, 66(4), 767-778. https://doi.org/10.1017/S0043933910000723
Lacasse, C., Gamble, K. C., & Boothe, D. M. (2013). Pharmacokinetics of a single dose of intravenous and oral meloxicam in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus). Journal of Avian Medicine and Surgery, 27, 204-210. https://doi.org/10.1647/2012-044
Lees, P., & Aliabadi, F. S. (2002). Rational dosing of antimicrobial drugs: Animals versus humans. International Journal of Antimicrobial Agents, 19, 269-284. https://doi.org/10.1016/S0924-8579(02)00025-0
Lindemann, D. M., Carpenter, J. W., & KuKanich, B. (2016). Pharmacokinetics of a single dose of oral and subcutaneous meloxicam in Caribbean flamingos (Phoenicopterus ruber ruber). Journal of Avian Medicine and Surgery, 30, 14-22. https://doi.org/10.1647/2014-065
Marx, K. L. (2006). Therapeutic agents. In G. J. Harrison, & T. L. Lightfoot (Eds.), Clinical avian medicine (p. 293). Palm Beach, FL: Spix Publishing.
McGeown, D., Danbury, T. C., Waterman-Pearson, A. E., & Kestin, S. C. (1999). Effect of carprofen on lameness in broiler chickens. Veterinary Record, 144, 668-671. https://doi.org/10.1136/vr.144.24.668 http://doi.org/
Molter, C. M., Court, M. H., Cole, G. A., Gagnon, D. J., Hazarika, S., & Paul-Murphy, J. R. (2013). Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis). American Journal of Veterinary Research, 74, 375-380. https://doi.org/10.2460/ajvr.74.3.375
Montesinos, A., Ardiaca, M., Gilabert, A., Bonvehí, C., Oros, J., & Encinas, T. (2017). Pharmacokinetics of meloxicam after intravenous, intramuscular and oral administration of a single dose to African grey parrots (Psittacus erithacus). Journal of Veterinary Pharmacology and Therapeutics, 40, 279-284. https://doi.org/10.1111/jvp.12350
Naidoo, V., Wolter, K., Cromarty, A. D., Bartels, P., Bekker, L., Mcgaw, L., … Swan, G. E. (2008). The pharmacokinetics of meloxicam in vultures. Journal of Veterinary Pharmacology and Therapeutics, 31, 128-134. https://doi.org/10.1111/j.1365-2885.2007.00923.x
Pereira, M. E., & Werther, K. (2007). Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus). Veterinary Record, 160(24), 844-846. https://doi.org/10.1136/vr.160.24.844
Pollock, C., Carpenter, J. W., & Antinoff, N. (2005). Nonsteroidal antiinflammatory agents used in birds. In J. W. Carpenter (Ed.), Exotic animal formulary (pp. 220-222). St Louis, MO: Elsevier Inc.
Proudfoot, F. G., & Hulan, H. W. (1983). Effects of dietary aspirin (acetylsalicylic acid) on the incidence of sudden death syndrome and the general performance of broiler chickens. Canadian Journal of Animal Science, 63, 469-471. https://doi.org/10.4141/cjas83-056
Riviere, J. E., Martin-Jimenez, T., Sundlof, S. F., & Craigmill, A. L. (1997). Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species. Journal of Veterinary Pharmacology and Therapeutics, 20, 453-463. https://doi.org/10.1046/j.1365-2885.1997.00095.x
Shlosberg, A., Bellaiche, M., Hanji, V., Nyska, A., Lublin, A., Shemesh, M., … Berman, E. (1996). The effect of acetylsalicylic acid and cold stress on the susceptibility of broilers to the ascites syndrome. Avian Pathology, 25, 581-590. https://doi.org/10.1080/03079459608419163
Souza, M. J., Bailey, J., White, M., Gordon, K., Gerhardt, L., & Cox, S. K. (2018). Pharmacokinetics and egg residues of meloxicam after multiple day oral dosing in domestic chickens. Journal of Avian Medicine and Surgery, 32(1), 8-12. https://doi.org/10.1647/22016-227
Souza, M. J., Bergman, J. B., White, M. S., Gordon, K. I., Gerhardt, L. E., & Cox, S. K. (2017). Pharmacokinetics and egg residues after oral administration of a single dose of meloxicam in domestic chickens (Gallus domesticus). American Journal of Veterinary Research, 78(8), 965-968. https://doi.org/10.2460/ajvr.78.8.965
Summa, N. M., Guzman, D. S., Larrat, S., Troncy, E., Bird, D. M., Lair, S., & Fitzgerald, G. (2017). Evaluation of high dosages of oral meloxicam in American kestrels (Falco sparverius). Journal of Avian Medicine and Surgery, 31(2), 108-116. https://doi.org/10.1647/2015-150
Thomas, J. M., Nakaue, H. S., & Reid, B. L. (1966). Effect of increasing dietary levels of acetylsalicylic acid on performance and cecal microbial counts of white leghorn pullets. Poultry Science, 45, 1313-1317. https://doi.org/10.3382/ps.0451313
Toutain, P. L., & Cester, C. C. (2004). Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint. American Journal of Veterinary Researc, 65, 1533-1541. https://doi.org/10.2460/ajvr.2004.65.1533
Toutain, P. L., & Lassourd, V. (2002). Pharmacokinetic/pharmacodynamic approach to assess irrelevant plasma or urine drug concentrations in postcompetition samples for drug control in the horse. Equine Veterinary Journal, 34, 242-249. https://doi.org/10.2746/042516402776185985
Zollinger, T. J., Hoover, J. P., Payton, M. E., & Schiller, C. A. (2011). Clinicopathologic, gross necropsy, and histologic findings after intramuscular injection of carprofen in a pigeon (Columba livia) model. Journal of Avian Medicine and Surgery, 25(3), 173-184. https://doi.org/10.1647/2010-023