Testing gene by community disadvantage moderation of sexual health outcomes among urban women.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
02
2019
accepted:
05
09
2019
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
17
3
2020
Statut:
epublish
Résumé
We examined whether the interplay between community disadvantage and a conduct disorder polygenic risk score (CD PRS) was associated with sexual health outcomes among urban women. Participants (N = 511; 75.5% African American) were originally recruited to participate in a school-based intervention and were followed into adulthood. Community disadvantage was calculated using census data when participants were in first grade. At age 20, blood or saliva samples were collected and participants reported on their condom use, sexual partners, and sexually transmitted infections. A CD PRS was created based on a genome-wide association study conducted by Dick et al. [2010]. Higher levels of community disadvantage was associated with greater sexually transmitted infections among women with a higher CD PRS. Implications of the study findings are discussed.
Identifiants
pubmed: 31581256
doi: 10.1371/journal.pone.0223311
pii: PONE-D-19-02489
pmc: PMC6776350
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0223311Subventions
Organisme : NIDA NIH HHS
ID : K01 DA042134
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA042138
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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