The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.
DNA methylation
DNA methyltransferase
DNMT3A
R882H
cancer
cancer biology
epigenetics
oligomer
oligomerization
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 11 2019
08 11 2019
Historique:
received:
09
07
2019
revised:
27
09
2019
pubmed:
5
10
2019
medline:
11
6
2020
entrez:
5
10
2019
Statut:
ppublish
Résumé
DNMT3A (DNA methyltransferase 3A) is a
Identifiants
pubmed: 31582562
pii: S0021-9258(20)30537-8
doi: 10.1074/jbc.RA119.010126
pmc: PMC6851320
doi:
Substances chimiques
DNMT3A protein, human
0
DNA
9007-49-2
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
DNA Methyltransferase 3A
EC 2.1.1.37
Banques de données
PDB
['2QRV', '5YX2']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16966-16977Informations de copyright
© 2019 Nguyen et al.
Déclaration de conflit d'intérêts
The authors have declared a conflict of interest. Competing financial interests are as follows: T.-V. N., S. Y., A. R., A. S., R. D., M. W., P. G. S., N. L., L. Y., P. Z., P. F., F. H. V., and D. M. B. are all current or former employees of H3 Biomedicine, Inc. Y. W. declares no competing financial interests.
Références
Cancer Cell. 2014 Apr 14;25(4):442-54
pubmed: 24656771
J Cell Biochem. 2005 Aug 1;95(5):902-17
pubmed: 15861382
Cancer Res. 2019 Jul 15;79(14):3583-3594
pubmed: 31164355
Oncogene. 2010 Jun 24;29(25):3723-31
pubmed: 20400977
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2620-5
pubmed: 24497509
Leukemia. 2016 Jun;30(6):1388-98
pubmed: 26876596
Cell Res. 2011 Aug;21(8):1172-81
pubmed: 21606950
Cancer Cell. 2016 Jul 11;30(1):92-107
pubmed: 27344947
Blood. 2013 Dec 12;122(25):4086-9
pubmed: 24167195
Nat Genet. 2011 Dec 04;44(1):23-31
pubmed: 22138693
J Biol Chem. 2006 Sep 8;281(36):25893-902
pubmed: 16829525
J Biol Chem. 2002 Oct 11;277(41):38746-54
pubmed: 12138111
Development. 2002 Apr;129(8):1983-93
pubmed: 11934864
Medicine (Baltimore). 2016 May;95(18):e3519
pubmed: 27149454
N Engl J Med. 2010 Dec 16;363(25):2424-33
pubmed: 21067377
Nature. 2007 Sep 13;449(7159):248-51
pubmed: 17713477
J Biol Chem. 2010 Sep 17;285(38):29091-100
pubmed: 20630873
J Clin Invest. 2017 Oct 2;127(10):3657-3674
pubmed: 28872462
Sci Rep. 2018 Sep 5;8(1):13242
pubmed: 30185810
J Biol Chem. 2012 Sep 7;287(37):30941-51
pubmed: 22722925
Genomics. 2000 May 1;65(3):293-8
pubmed: 10857753
Nucleic Acids Res. 2011 Jul;39(12):4984-5002
pubmed: 21378119
J Biol Chem. 2014 Oct 24;289(43):29602-13
pubmed: 25147181
Cell. 1999 Oct 29;99(3):247-57
pubmed: 10555141
J Biol Chem. 2001 Aug 24;276(34):32282-7
pubmed: 11427539
Cytogenet Cell Genet. 2001;92(1-2):122-6
pubmed: 11306809
Arch Biochem Biophys. 2010 Jun 1;498(1):13-22
pubmed: 20227382
Proc Natl Acad Sci U S A. 2017 May 16;114(20):5237-5242
pubmed: 28461508
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Nature. 2018 Feb 15;554(7692):387-391
pubmed: 29414941
Mol Cell Biol. 2004 Oct;24(20):9048-58
pubmed: 15456878
J Biol Chem. 2010 Aug 20;285(34):26114-20
pubmed: 20547484
Nucleic Acids Res. 2019 Jan 10;47(1):152-167
pubmed: 30321403
N Engl J Med. 2009 Sep 10;361(11):1058-66
pubmed: 19657110
Nature. 2015 Jan 29;517(7536):640-4
pubmed: 25383530
J Biol Chem. 2011 Dec 2;286(48):41479-88
pubmed: 21979949
Nat Rev Genet. 2018 Feb;19(2):81-92
pubmed: 29033456
J Biol Chem. 2005 Apr 8;280(14):13341-8
pubmed: 15671018
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16916-21
pubmed: 12481029
Science. 2001 Dec 21;294(5551):2536-9
pubmed: 11719692
Cell Stem Cell. 2014 Sep 4;15(3):350-364
pubmed: 25130491
J Exp Med. 2007 Apr 16;204(4):715-22
pubmed: 17420264
Mol Cell Biol. 2003 Aug;23(16):5594-605
pubmed: 12897133
J Biol Chem. 2004 Jun 11;279(24):25447-54
pubmed: 14998998
J Biol Chem. 2011 Jul 8;286(27):24200-7
pubmed: 21566127
J Biol Chem. 2004 Jun 25;279(26):27816-23
pubmed: 15105426
Cell. 2017 Feb 23;168(5):801-816.e13
pubmed: 28215704