Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status.
Journal
Journal of analytical methods in chemistry
ISSN: 2090-8865
Titre abrégé: J Anal Methods Chem
Pays: Egypt
ID NLM: 101575377
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
06
2019
accepted:
24
07
2019
entrez:
5
10
2019
pubmed:
5
10
2019
medline:
5
10
2019
Statut:
epublish
Résumé
The purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to VOCs in women and infants. This review included 20 previously published eligible studies. VOC analysis has allowed us to highlight differences in lifestyles, intestinal microbiota, and metabolism. New innovative methods have been described that allow the detection and quantification of a broad spectrum of metabolites present in exhaled breath even at very low levels, some of which have been shown to be indicators of pathological conditions. Five studies were analyzed that involved VOC analysis in relation to type of diet. All of them showed that the type of diet can have an impact on metabolites excreted and therefore can be a useful tool in the nutritional studies related to metabolism and health and disease status. Two studies concerned VOC analysis in inflammatory bowel diseases, and the results showed that VOCs can distinguish active disease from remission; VOC profile is clearly different in patients. In particular, C VOC analysis allowed to highlight differences in behavior, lifestyle, and metabolism of individuals. Analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers.
Identifiants
pubmed: 31583160
doi: 10.1155/2019/7247802
pmc: PMC6754926
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7247802Informations de copyright
Copyright © 2019 Mariangela Rondanelli et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
FASEB J. 2007 Jun;21(8):1675-88
pubmed: 17314143
J Breath Res. 2014 Mar;8(1):014001
pubmed: 24421258
Pediatr Obes. 2015 Feb;10(1):23-9
pubmed: 24677760
Aliment Pharmacol Ther. 2017 May;45(9):1244-1254
pubmed: 28239876
Nutr Res. 2016 Jun;36(6):612-9
pubmed: 27188907
J Breath Res. 2010 Jun;4(2):026002
pubmed: 21383470
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):455-60
pubmed: 21681085
Br J Surg. 2013 Jan;100(1):144-50
pubmed: 23212621
Clin Exp Allergy. 2013 Jul;43(7):705-15
pubmed: 23786277
J Breath Res. 2016 Nov 03;10(4):041001
pubmed: 27811380
Anal Bioanal Chem. 2010 Jan;396(2):739-50
pubmed: 19844696
J Breath Res. 2015 Apr 20;9(2):026005
pubmed: 25891965
Int J Cancer. 2010 Jun 1;126(11):2663-70
pubmed: 19839051
J Breath Res. 2016 Jun 24;10(3):037101
pubmed: 27341527
Sci Rep. 2017 Nov 15;7(1):15636
pubmed: 29142292
Ann Surg. 2015 Dec;262(6):981-90
pubmed: 25575255
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:86-92
pubmed: 29524697
J Environ Monit. 2010 Jun;12(6):1265-73
pubmed: 20358052
Cancer Biol Ther. 2014 Feb;15(2):200-6
pubmed: 24100612
Anal Chem. 2010 Mar 1;82(5):2139-44
pubmed: 20143891
J Breath Res. 2013 Sep;7(3):037104
pubmed: 23774130
J Nutr. 2017 Nov;147(11):2067-2075
pubmed: 28954842