Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.
Hematopoietic stem cells
Humanized mice
NSG mice
Thymectomy
Thymopoiesis
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
05
04
2019
revised:
30
07
2019
accepted:
03
10
2019
pubmed:
5
10
2019
medline:
11
7
2020
entrez:
5
10
2019
Statut:
ppublish
Résumé
We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice.
Identifiants
pubmed: 31583677
doi: 10.1002/eji.201948205
pmc: PMC6940512
mid: NIHMS1055405
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-141Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK103585
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK064819
Pays : United States
Organisme : NIH HHS
ID : S10 OD020056
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIDDK NIH HHS
ID : RRID: SCR_014393
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063608
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027050
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK104207
Pays : United States
Organisme : NIH HHS
ID : S10 OD025218
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI045897
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106436
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123559
Pays : United States
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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