Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression.
Adaptation, Psychological
/ physiology
Catechol O-Methyltransferase
/ genetics
Depression
/ genetics
Depressive Disorder, Major
/ genetics
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome-Wide Association Study
/ methods
Humans
Neuropeptide Y
/ genetics
Resilience, Psychological
/ classification
Serotonin Plasma Membrane Transport Proteins
/ genetics
Stress Disorders, Post-Traumatic
/ genetics
Stress, Psychological
/ genetics
depression
genetic risk factors
posttraumatic stress disorder
resilience
vulnerability
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
09
04
2019
revised:
22
07
2019
accepted:
03
09
2019
pubmed:
5
10
2019
medline:
5
1
2021
entrez:
5
10
2019
Statut:
ppublish
Résumé
Resilience is the ability to cope with critical situations through the use of personal and socially mediated resources. Since a lack of resilience increases the risk of developing stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), a better understanding of the biological background is of great value to provide better prevention and treatment options. Resilience is undeniably influenced by genetic factors, but very little is known about the exact underlying mechanisms. A recently published genome-wide association study (GWAS) on resilience has identified three new susceptibility loci, DCLK2, KLHL36, and SLC15A5. Further interesting results can be found in association analyses of gene variants of the stress response system, which is closely related to resilience, and PTSD and MDD. Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience. GWAS on PTSD and MDD provide another approach to identifying new disease-associated loci and, although the functional significance for disease development for most of these risk genes is still unknown, they are potential candidates due to the overlap of stress-related psychiatric disorders and resilience. In the future, it will be important for genetic studies to focus more on resilience than on pathological phenotypes, to develop reasonable concepts for measuring resilience, and to establish international cooperations to generate sufficiently large samples.
Identifiants
pubmed: 31583809
doi: 10.1002/ajmg.b.32763
doi:
Substances chimiques
Neuropeptide Y
0
SLC6A4 protein, human
0
Serotonin Plasma Membrane Transport Proteins
0
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-94Informations de copyright
© 2019 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.
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