Individual periodic limb movements with arousal are temporally associated with nonsustained ventricular tachycardia: a case-crossover analysis.
arrhythmia
nonsustained tachycardia
periodic limb movements
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
21 10 2019
21 10 2019
Historique:
received:
19
03
2019
revised:
30
05
2019
pubmed:
5
10
2019
medline:
14
5
2020
entrez:
5
10
2019
Statut:
ppublish
Résumé
Both periodic limb movements during sleep (PLMS) and arousals are associated with sympathetic nervous system activation and may be arrhythmogenic. We hypothesize a temporal relationship exists between individual PLMS, particularly with arousal, and nonsustained ventricular tachycardia (NSVT) events. A bidirectional time-stratified case-crossover design was used to assess temporal associations between PLMS and NSVT during sleep in 49 Osteoporotic Fractures in Men Sleep Study participants with NSVT in a community-based cohort (n = 2,911). Sleep time was divided into approximate 30-min segments. For each NSVT (n = 141), we selected a preceding 30-s hazard period and three randomly chosen 30-s control periods from sleep within the same segment and evaluated for PLMS, respiratory events, minimum saturation, and arousals. Odds ratios and 95% confidence intervals-OR (95% CI)-were determined by conditional logistic regression; covariates included EEG arousals, minimum saturation, and respiratory events in the same hazard/control period. Participants with NSVT were 79.5 ± 6.2 years with a PLMS index of 32.1 (IQR: 10.1, 61.4) and apnea-hypopnea index of 17.1 (IQR: 9.4, 26.1). PLMS without arousal were not significantly associated with NSVT (OR = 0.80, 95% CI: 0.41-1.59). PLMS with arousal were associated with NSVT in unadjusted analyses (OR = 2.50, 95% CI: 1.11-5.65) and after adjustment (OR = 2.31, 95% CI: 1.02-5.25). Arousals associated with PLMS were associated with NSVT in unadjusted (OR = 2.84, 95% CI: 1.23-6.56) and adjusted analyses (OR = 2.61, 95% CI: 1.13-6.05). PLMS with (but not without) arousals are temporally associated with a greater than twofold higher odds of subsequent NSVT episodes. PLMS-related arousals may be physiologically important ventricular arrhythmia triggers. ClinicalTrials.gov, NCT00070681.
Identifiants
pubmed: 31585012
pii: 5533205
doi: 10.1093/sleep/zsz165
pmc: PMC6802566
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT00070681']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL109493
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042145
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042140
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135818
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000128
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042143
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070838
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070842
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG027810
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070839
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR066160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071194
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL108226
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042124
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070847
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042139
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070841
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070837
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070848
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042168
Pays : United States
Investigateurs
K L Stone
(KL)
D C Bauer
(DC)
S R Cummings
(SR)
N Goldschlager
(N)
P Varosy
(P)
K Yaffe
(K)
P M Cawthon
(PM)
R Fullman
(R)
R Benard
(R)
T Blackwell
(T)
L Concepcion
(L)
J Diehl
(J)
S Ewing
(S)
C Fox
(C)
M Jaime-Chavez
(M)
E Kwan
(E)
S Litwack
(S)
W Liu
(W)
L Y Lui
(LY)
J Schneider
(J)
R Scott
(R)
D Tanaka
(D)
J Ziarno
(J)
E Orwoll
(E)
K Phipps
(K)
L Marshall
(L)
J Babich Blank
(J)
L Lambert
(L)
B Chan
(B)
D Neevel
(D)
C E Lewis
(CE)
J Shikany
(J)
P Johnson
(P)
C Oden
(C)
S House
(S)
N Webb
(N)
K Hardy
(K)
S Felder
(S)
J Wilkoff
(J)
J King
(J)
T Johnsey
(T)
M Young
(M)
J Smith
(J)
C Sassaman
(C)
C Collier
(C)
C Atkins
(C)
K Ensrud
(K)
H Fink
(H)
D King
(D)
N Michaels
(N)
N Nelson
(N)
C Bird
(C)
D Blanks
(D)
F Imker-Witte
(F)
K Moen
(K)
M Paudel
(M)
M Slindee
(M)
M Stefanick
(M)
A Hoffman
(A)
K Kent
(K)
B Malig
(B)
S Wong
(S)
J Cauley
(J)
J Zmuda
(J)
M Danielson
(M)
L Harper
(L)
L Buck
(L)
M Nasim
(M)
D Cusick
(D)
M Gorecki
(M)
N Watson
(N)
C Bashada
(C)
C Newman
(C)
E Barrett-Connor
(E)
S Ancoli-Israel
(S)
T Dam
(T)
M L Carrion-Petersen
(ML)
P Miller
(P)
N Kamantigue
(N)
S Redline
(S)
S Surovec
(S)
N Scott
(N)
M Rueschman
(M)
N Johnson
(N)
J Arnold
(J)
R Nawabit
(R)
J Romaniuk
(J)
S Seicean
(S)
Informations de copyright
Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2019.
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