Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras.
brain organoid
chimera
consciousness
enhancement
ethics
transplantation
Journal
Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472
Informations de publication
Date de publication:
03 Oct 2019
03 Oct 2019
Historique:
entrez:
5
10
2019
pubmed:
5
10
2019
medline:
22
9
2020
Statut:
ppublish
Résumé
Recent demonstrations of human brain organoid transplantation in rodents have accentuated ethical concerns associated with these entities, especially as they relate to potential "humanization" of host animals. Consideration of established scientific principles can help define the realistic range of expected outcomes in such transplantation studies. This practical approach suggests that augmentation of discrete brain functions in transplant hosts is a more relevant ethical question in the near term than the possibility of "conscious" chimeric animals. We hope that this framework contributes to a balanced approach for proceeding with studies involving brain organoid transplantation and other forms of human-animal brain chimeras.
Identifiants
pubmed: 31585092
pii: S1934-5909(19)30387-X
doi: 10.1016/j.stem.2019.09.002
pmc: PMC7180006
mid: NIHMS1580000
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
462-472Subventions
Organisme : RRD VA
ID : IK2 RX002013
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH106434
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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