Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury.

Animals Bile Acids and Salts / metabolism Ethanol / adverse effects Fatty Acids, Omega-3 / metabolism Fatty Acids, Omega-6 / metabolism Feces / chemistry Female Gastrointestinal Microbiome / drug effects Homeostasis / drug effects Intestinal Mucosa / drug effects Lipopolysaccharides / pharmacology Mice Mice, Inbred C57BL
alcoholic liver disease bile acid metabolism diet and dietary lipids gut microbiome inflammation intestine omega-3 fatty acids polyunsaturated fatty acid

Journal

Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606

Informations de publication

Date de publication:
12 2019
Historique:
received: 15 06 2019
revised: 22 09 2019
pubmed: 6 10 2019
medline: 11 7 2020
entrez: 6 10 2019
Statut: ppublish

Résumé

Ethanol (EtOH)-induced alterations in intestinal homeostasis lead to multi-system pathologies, including liver injury. ω-6 PUFAs exert pro-inflammatory activity, while ω-3 PUFAs promote anti-inflammatory activity that is mediated, in part, through specialized pro-resolving mediators [e.g., resolvin D1 (RvD1)]. We tested the hypothesis that a decrease in the ω-6:ω-3 PUFA ratio would attenuate EtOH-mediated alterations in the gut-liver axis. ω-3 FA desaturase-1 (

Identifiants

DOI: 10.1194/jlr.RA119000200 PMID: 31586017 PMC: PMC6889711
pubmed: 31586017
pii: S0022-2275(20)31042-7
doi: 10.1194/jlr.RA119000200
pmc: PMC6889711
doi:

Substances chimiques

Bile Acids and Salts 0
Fatty Acids, Omega-3 0
Fatty Acids, Omega-6 0
Lipopolysaccharides 0
Ethanol 3K9958V90M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2034-2049

Subventions

Organisme : NIAAA NIH HHS
ID : R01 AA024102
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113226
Pays : United States
Organisme : NIAAA NIH HHS
ID : L30 AA027913
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA024337
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103436
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM106396
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA023681
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA028423
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA022489
Pays : United States
Organisme : BLRD VA
ID : I01 BX000350
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027926
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021893
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021901
Pays : United States
Organisme : NIH HHS
ID : S10 OD020106
Pays : United States
Organisme : NIAAA NIH HHS
ID : F32 AA027950
Pays : United States

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Auteurs

Dennis R Warner (DR)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
ORCID: 0000-0002-5303-6870

Jeffrey B Warner (JB)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Department of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.

Josiah E Hardesty (JE)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.

Ying L Song (YL)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.

Taylor N King (TN)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.

Jing X Kang (JX)

Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Chih-Yu Chen (CY)

Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Shanfu Xie (S)

Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Fang Yuan (F)

Department of Chemistry, University of Louisville, Louisville, KY.

Md Aminul Islam Prodhan (MAI)

Department of Chemistry, University of Louisville, Louisville, KY.

Xipeng Ma (X)

Department of Chemistry, University of Louisville, Louisville, KY.

Xiang Zhang (X)

Department of Chemistry, University of Louisville, Louisville, KY.

Eric C Rouchka (EC)

Department of Computer Engineering and Computer Science, Speed School of Engineering, University of Louisville, Louisville, KY.

Krishna Rao Maddipati (KR)

Department of Pathology, Wayne State University School of Medicine, Detroit, MI.

Joan Whitlock (J)

Department of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.

Eric C Li (EC)

Department of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.

Gary P Wang (GP)

Department of Medicine Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL.

Craig J McClain (CJ)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY.
Department of Pharmacology and Toxicology and University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY.
Robley Rex Veterans Medical Center, Louisville, KY.

Irina A Kirpich (IA)

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY i0kirp01@louisville.edu.
Department of Pharmacology and Toxicology and University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Decreased ω-6:ω-3 PUFA ratio attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Decreased ω-6:ω-3 PUFA ratio attenuates...