Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Acromegaly
Aryl hydrocarbon receptor pathway
Molecular chaperone
Pituitary adenoma
Somatotroph
Somatotropinoma
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
14
08
2019
revised:
28
09
2019
accepted:
30
09
2019
pubmed:
7
10
2019
medline:
21
10
2020
entrez:
7
10
2019
Statut:
ppublish
Résumé
The cAMP-PKA pathway plays an essential role in the pituitary gland, governing cell differentiation and survival, and maintenance of endocrine function. Somatotroph growth hormone transcription and release as well as cell proliferation are regulated by the cAMP-PKA pathway; cAMP-PKA pathway abnormalities are frequently detected in sporadic as well as in hereditary somatotroph tumors and more rarely in other pituitary tumors. Inactivating variants of the aryl hydrocarbon receptor-interacting protein (AIP)-coding gene are the genetic cause of a subset of familial isolated pituitary adenomas (FIPA). Multiple functional links between the co-chaperone AIP and the cAMP-PKA pathway have been described. This review explores the role of chaperones including AIP in normal pituitary function as well as in somatotroph tumors, and their interaction with the cAMP-PKA pathway.
Identifiants
pubmed: 31586652
pii: S0303-7207(19)30309-0
doi: 10.1016/j.mce.2019.110607
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Molecular Chaperones
0
aryl hydrocarbon receptor-interacting protein
0
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110607Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.