Depression, isotretinoin, and folic acid: A practical review.
depression
folic acid
low dose isotretinoin
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
09
08
2019
accepted:
26
09
2019
pubmed:
7
10
2019
medline:
19
5
2020
entrez:
7
10
2019
Statut:
ppublish
Résumé
Isotretinoin (ISO) is a first-generation retinoid discovered in 1952 and approved by the FDA for the treatment of nodulocystic acne in 1982. The anti-inflammatory properties of ISO have found its use in disorders other than acne. ISO can create psychiatric problems, including depression and suicidal ideation. These neuropsychiatric problems are very similar to disorders secondary to hyperhomocysteinemia (HHcy), vitamin B12, and folic acid (vitamin B9) deficiencies. Given that previous literature suggested folate supplementation improved the efficacy of traditional antidepressant medications, clinicians may wish to consider folate supplementation for patients with depression or possible depressive symptoms, such as acne patients with genetic susceptibility. Brain-derived neurotrophic factor may be a cytokine-specific screening biomarker in immune-based antidepressive therapy.
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Fatty Acids
0
Folic Acid
935E97BOY8
Isotretinoin
EH28UP18IF
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13104Informations de copyright
© 2019 Wiley Periodicals, Inc.
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