Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.

Aged Aged, 80 and over Brain Ischemia / genetics Chromosomes, Human, Pair 14 / genetics Female Genome-Wide Association Study Humans Leukocyte Count Leukocytes / immunology Male Middle Aged Polymorphism, Single Nucleotide Prognosis Stroke / genetics
genome-wide association study humans leukocytes risk factors stroke

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
12 2019
Historique:
pubmed: 8 10 2019
medline: 9 4 2020
entrez: 8 10 2019
Statut: ppublish

Résumé

Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (

Identifiants

DOI: 10.1161/STROKEAHA.119.026593 PMID: 31587654 PMC: PMC6878188
pubmed: 31587654
doi: 10.1161/STROKEAHA.119.026593
pmc: PMC6878188
mid: NIHMS1539961
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3618-3621

Subventions

Organisme : NINDS NIH HHS
ID : K23 NS099487
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085419
Pays : United States

Références

Neurology. 2019 Mar 19;92(12):e1271-e1283
pubmed: 30796134
J Stroke Cerebrovasc Dis. 2012 Nov;21(8):819-24
pubmed: 21703875
Hum Mol Genet. 2014 Dec 20;23(25):6944-60
pubmed: 25096241
Circ Res. 2019 Jan 4;124(1):114-120
pubmed: 30582445
Haematologica. 2013 Jul;98(7):1115-23
pubmed: 23349302
Hum Mol Genet. 2017 Mar 15;26(6):1193-1204
pubmed: 28158719

Auteurs

Nuria P Torres-Aguila (NP)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain (N.P.T.-A., C.C., J.M.).

Caty Carrera (C)

Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain (N.P.T.-A., C.C., J.M.).

Anne-Katrine Giese (AK)

Neurology Department, Massachusetts General Hospital, Boston (A.-K.G., N.S.R.).

Natalia Cullell (N)

Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).

Elena Muiño (E)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).

Jara Cárcel-Márquez (J)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).

Cristina Gallego-Fabrega (C)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).

Jonathan González-Sánchez (J)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).
School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom (J.G.-S., J.K.).

María Del Mar Freijo (M)

Neurology Department, Hospital de Basurto, Bilbao, Spain (M.d.M.F.).

José Álvarez-Sabín (J)

Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).

Carlos Molina (C)

Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).

Marc Ribó (M)

Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).

Jordi Jimenez-Conde (J)

Neurology Department, Institut Hospital del Mar d'Investigacions Mèdiques-Hospital del Mar Barcelona, Spain (J.J.-C., J.R.).
Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain (J.J.-C., J.R.).
Universitat Autónoma de Barcelona/Departamento de Ciencias Experimentales y de la Salud, Universitat Pompeu Fabra, Barcelona, Spain (J.J.-C., J.R.).

Jaume Roquer (J)

Neurology Department, Institut Hospital del Mar d'Investigacions Mèdiques-Hospital del Mar Barcelona, Spain (J.J.-C., J.R.).
Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain (J.J.-C., J.R.).
Universitat Autónoma de Barcelona/Departamento de Ciencias Experimentales y de la Salud, Universitat Pompeu Fabra, Barcelona, Spain (J.J.-C., J.R.).

Tomás Sobrino (T)

Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).

Francisco Campos (F)

Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).

José Castillo (J)

Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).

Lucia Muñoz-Narbona (L)

Neurosciences Department, Hospital Germans Trias I Pujol-Universitat Autónoma de Barcelona, Barcelona, Spain (L.M.-N., A.D.).

Elena Lopez-Cancio (E)

Stroke Unit, Hospital Universitario Central de Asturias, Oviedo, Spain (E.L.-C.).

Antoni Dàvalos (A)

Neurosciences Department, Hospital Germans Trias I Pujol-Universitat Autónoma de Barcelona, Barcelona, Spain (L.M.-N., A.D.).

Rosa Diaz-Navarro (R)

Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).

Silvia Tur (S)

Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).

Cristòfol Vives-Bauza (C)

Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).

Gemma Serrano-Heras (G)

Neurology Department, University Hospital of Albacete, Spain (G.S.-H., T.S.).

Tomás Segura (T)

Neurology Department, University Hospital of Albacete, Spain (G.S.-H., T.S.).

Jerzy Krupinski (J)

School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom (J.G.-S., J.K.).
Neurology Service, Hospital Universitari Mútua Terrassa, Spain (J.K.).

Raquel Delgado-Mederos (R)

Stroke Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (R.D.-M., J.M.-F.).

Joan Martí-Fàbregas (J)

Stroke Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (R.D.-M., J.M.-F.).

Laura Heitsch (L)

Emergency Medicine (L.H.), Washington University School of Medicine, Saint Louis, MO.
Neurology Department (L.H., J.-M.L.), Washington University School of Medicine, Saint Louis, MO.

Laura Ibañez (L)

Psychiatry Department (L.I., C.C.), Washington University School of Medicine, Saint Louis, MO.

Carlos Cruchaga (C)

Psychiatry Department (L.I., C.C.), Washington University School of Medicine, Saint Louis, MO.

Natalia S Rost (NS)

Neurology Department, Massachusetts General Hospital, Boston (A.-K.G., N.S.R.).

Joan Montaner (J)

Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain (N.P.T.-A., C.C., J.M.).
Stroke Research Program, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/University of Seville (J.M.).
Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain (J.M.).

Jin-Moo Lee (JM)

Neurology Department (L.H., J.-M.L.), Washington University School of Medicine, Saint Louis, MO.

Israel Fernandez-Cadenas (I)

From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 13-15 › Chromosomes humains de la paire 14 › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Diagnostic › Pronostic › Genome-Wide Association Study of White Blood...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Genome-Wide Association Study of White Blood...