Severe recurrent aphthous stomatitis treated with adalimumab: A case report in a teenage patient.
RAS
TNF-α
adalimumab
anti-TNF
aphthous stomatitis
Journal
Pediatric dermatology
ISSN: 1525-1470
Titre abrégé: Pediatr Dermatol
Pays: United States
ID NLM: 8406799
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
pubmed:
8
10
2019
medline:
6
5
2020
entrez:
8
10
2019
Statut:
ppublish
Résumé
Recurrent aphthous stomatitis (RAS) is a chronic disorder of unknown etiology characterized by recurring ulcers involving the oral mucosa in patients with no other manifestations. It is a common cause of oral ulcers in children. In its major form, RAS can be a severe and disabling disorder due to pain and scarring, and poses a therapeutic challenge. Therapies for major RAS include prednisone, thalidomide, colchicine, and dapsone. However, many patients do not achieve adequate control of the disease with them (J Clin Diagn Res, 10, 2016 and ZE08). We report a case of severe RAS in a teenager with a dramatic response to adalimumab.
Substances chimiques
Anti-Inflammatory Agents
0
Adalimumab
FYS6T7F842
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
986-987Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Ranganath SP, Pai A. Is optimal management of recurrent aphthous stomatitis possible? A reality check. J Clin Diagn Res JCDR. 2016;10:ZE08-ZE13.
Sánchez-Cano D, Callejas-Rubio JL, Ruiz-Villaverde R, Ortego-Centeno N. Recalcitrant, recurrent aphthous stomatitis successfully treated with adalimumab. J Eur Acad Dermatol Venereol JEADV. 2009;23:206.
Hegde S, Ajila V, Babu S, et al. Evaluation of salivary tumour necrosis factor-alpha in patients with recurrent aphthous stomatitis. Eur Oral Res. 2019;52:157-161.
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Poddighe D, Mukusheva Z, Dauyey K, Assylbekova M. Adalimumab in the treatment of pediatric Behçet's disease: case-based review. Rheumatol Int. 2019;3:1107-1112.