Expert statement on the ICU management of patients with thrombotic thrombocytopenic purpura.
Acute kidney injury
Auto-immune disease
Cardiac failure
Hemolysis
Plasma exchange
Thrombocytopenia
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
05
07
2019
accepted:
07
08
2019
pubmed:
8
10
2019
medline:
17
6
2020
entrez:
8
10
2019
Statut:
ppublish
Résumé
Thrombotic thrombocytopenic purpura (TTP) is fatal in 90% of patients if left untreated and must be diagnosed early to optimize patient outcomes. However, the very low incidence of TTP is an obstacle to the development of evidence-based clinical practice recommendations, and the very wide variability in survival rates across centers may be partly ascribable to differences in management strategies due to insufficient guidance. We therefore developed an expert statement to provide trustworthy guidance about the management of critically ill patients with TTP. As strong evidence was difficult to find in the literature, consensus building among experts could not be reported for most of the items. This expert statement is timely given the recent advances in the treatment of TTP, such as the use of rituximab and of the recently licensed drug caplacizumab, whose benefits will be maximized if the other components of the management strategy follow a standardized pattern. Finally, unanswered questions are identified as topics of future research on TTP.
Identifiants
pubmed: 31588978
doi: 10.1007/s00134-019-05736-5
pii: 10.1007/s00134-019-05736-5
doi:
Substances chimiques
Adrenal Cortex Hormones
0
ADAMTS13 Protein
EC 3.4.24.87
ADAMTS13 protein, human
EC 3.4.24.87
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1518-1539Commentaires et corrections
Type : ErratumIn
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