Aqueous Extract of Matricaria pubescens Exhibits Antihypertensive Activity in L-NAME-induced Hypertensive Rats through its Vasorelaxant Effect.
Cyclooxygenase
K+ channels
L-NAME
hypertension
pathways
sGC-cGMP
vasorelaxant.
Journal
Cardiovascular & hematological agents in medicinal chemistry
ISSN: 1875-6182
Titre abrégé: Cardiovasc Hematol Agents Med Chem
Pays: Netherlands
ID NLM: 101266881
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
07
2019
revised:
07
09
2019
accepted:
12
09
2019
pubmed:
8
10
2019
medline:
15
1
2020
entrez:
8
10
2019
Statut:
ppublish
Résumé
Matricaria pubescens is a medicinal plant from North Africa. This plant is widely used in alternative medicine as a remedy against rheumatism, inflammation, diabetes and hypertension. The aim of the study was to evaluate the possible antihypertensive and vasodilator activity of the aqueous extract of Matricaria pubescens (M. pubescens). In the current study, the aqueous extract of the aerial parts of M. pubescens (AEMP) was prepared and its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. The results indicated that AEMP reduced the systolic, diastolic, mean arterial blood pressure in hypertensive rats but not in normotensive rats. The data revealed that AEMP exhibits its antihypertensive effect through vasorelaxant activity. More interestingly, this study approved that the vasorelaxant capacity of AEMP seems to be mediated through vascular cyclooxygenase pathway, the opening of K+ channels and sGC-cGMP induction pathway. The study illustrates the beneficial action of M. pubescens as an antihypertensive agent.
Sections du résumé
BACKGROUND
BACKGROUND
Matricaria pubescens is a medicinal plant from North Africa. This plant is widely used in alternative medicine as a remedy against rheumatism, inflammation, diabetes and hypertension.
AIM
OBJECTIVE
The aim of the study was to evaluate the possible antihypertensive and vasodilator activity of the aqueous extract of Matricaria pubescens (M. pubescens).
MATERIAL AND METHODS
METHODS
In the current study, the aqueous extract of the aerial parts of M. pubescens (AEMP) was prepared and its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats.
RESULTS
RESULTS
The results indicated that AEMP reduced the systolic, diastolic, mean arterial blood pressure in hypertensive rats but not in normotensive rats. The data revealed that AEMP exhibits its antihypertensive effect through vasorelaxant activity. More interestingly, this study approved that the vasorelaxant capacity of AEMP seems to be mediated through vascular cyclooxygenase pathway, the opening of K+ channels and sGC-cGMP induction pathway.
CONCLUSION
CONCLUSIONS
The study illustrates the beneficial action of M. pubescens as an antihypertensive agent.
Identifiants
pubmed: 31589128
pii: CHAMC-EPUB-101232
doi: 10.2174/1871525717666191007151413
doi:
Substances chimiques
Antihypertensive Agents
0
Plant Extracts
0
Vasodilator Agents
0
NG-Nitroarginine Methyl Ester
V55S2QJN2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-143Informations de copyright
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