Preclinical Evaluation of Antitumoral and Cytotoxic Properties of Viscum album Fraxini Extract on Pediatric Tumor Cells.
Animals
Apoptosis
/ drug effects
Caspases
/ drug effects
Cell Cycle
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cytotoxins
/ pharmacology
Female
Humans
Male
Mice
Mitochondria
/ drug effects
Neuroblastoma
/ drug therapy
Pediatrics
Phytotherapy
Plant Extracts
/ pharmacology
Viscum album
/ chemistry
Journal
Planta medica
ISSN: 1439-0221
Titre abrégé: Planta Med
Pays: Germany
ID NLM: 0066751
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
8
10
2019
medline:
18
12
2019
entrez:
8
10
2019
Statut:
ppublish
Résumé
In Europe, especially in German-speaking countries, administration of mistletoe extracts is the most common and popular complementary and alternative therapy approach reported in oncology. Mistletoe therapy is applied to children with cancer for curative and palliative therapeutic regimes with increasing frequency, but at the same time, there are only a few studies on the effectiveness of this therapy. Therefore, we have investigated the response of various pediatric cell lines (acute myeloid leukemia, Ewing's sarcoma, hepatocellular carcinoma, medulloblastoma, neuroblastoma, and osteosarcoma) to mistletoe extract, abnobaVISCUM Fraxini. Effects on cell proliferation, cell cycle distribution as well as on mitochondrial integrity and caspase-mediated apoptosis were investigated in neuroblastoma cell lines, SH-SY5Y and Kelly. Additionally,
Substances chimiques
Cytotoxins
0
Plant Extracts
0
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1150-1159Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.