Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids.
cell membrane
mycobacteria
mycolic acids
triarabinoglycerol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Oct 2019
06 Oct 2019
Historique:
received:
12
08
2019
revised:
24
09
2019
accepted:
01
10
2019
entrez:
9
10
2019
pubmed:
9
10
2019
medline:
11
2
2020
Statut:
epublish
Résumé
Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties. A related di-mycoloyl tri-arabinofuranosyl glycerol fragment has been isolated from cell wall hydrolysates. An effective stereoselective synthesis of tri-arabinofuranosyl glycerol, followed by coupling with stereochemically defined mycolic acids of different structural classes, to provide unique di-mycoloyl tri-arabinofuranosyl glycerols is now described.
Identifiants
pubmed: 31590468
pii: molecules24193596
doi: 10.3390/molecules24193596
pmc: PMC6804083
pii:
doi:
Substances chimiques
Mycolic Acids
0
Trisaccharides
0
Arabinose
B40ROO395Z
Glycerol
PDC6A3C0OX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
There are no conflicts of interest for any of the authors of this paper.
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