Enriched Gellan Gum hydrogel as visco-supplement.

Animals Cell Proliferation Cell Survival Chondrocytes Elastic Modulus Humans Hydrogels / chemistry Mice NIH 3T3 Cells Osteoarthritis / drug therapy Polysaccharides, Bacterial / chemistry Polyvinyl Alcohol / chemistry Viscosity
Gellan Gum PVA Rheology STMP Swelling Viscosupplement

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Jan 2020
Historique:
received: 01 07 2019
revised: 29 08 2019
accepted: 18 09 2019
entrez: 9 10 2019
pubmed: 9 10 2019
medline: 13 2 2020
Statut: ppublish

Résumé

Viscosupplementation, i.e. intra-articular injection of hyaluronic acid derivatives, is considered as the most effective treatment for patients with mild to moderate osteoarthritis. Even if hyaluronic acid is still considered as the gold standard, research is now focusing on the development of new products with enhanced injectability and yet reasonable viscoelastic behavior for OA treatment. A Gellan Gum (GG) hydrogel was synthesized and coated with crosslinked polyvinyl alcohol (PVA) to protect the polysaccharide from degradation during sterilization and improve its performance for the foreseen application. Thermal analyses indicated that mixed hydrogel showed a higher degree of structuring than the bare polysaccharide core without losing its swelling properties, thanks to the hydrophylicity of both coating and cross-linking agent. The PVA coating increased elastic and viscous moduli of the polysaccharide core conferring it a higher resistance to shear and compression and better thixotropic properties. Despite the double crosslinking, hydrogel was injectable. Cytocompatibility towards chondrocytes was verified.

Identifiants

DOI: 10.1016/j.carbpol.2019.115347 PMID: 31590845
pubmed: 31590845
pii: S0144-8617(19)31014-8
doi: 10.1016/j.carbpol.2019.115347
pii:
doi:

Substances chimiques

Hydrogels 0
Polysaccharides, Bacterial 0
gellan gum 7593U09I4D
Polyvinyl Alcohol 9002-89-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115347

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Gemma Leone (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy. Electronic address: gemma.leone@unisi.it.

Marco Consumi (M)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy.

Simone Pepi (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy.

Alessio Pardini (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy.

Claudia Bonechi (C)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.

Gabriella Tamasi (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.

Alessandro Donati (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.

Stefania Lamponi (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy.

Claudio Rossi (C)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.

Agnese Magnani (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy. Electronic address: agnese.magnani@unisi.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Élasticité › Module d'élasticité › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules NIH 3T3 › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Polyosides bactériens › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Poly(alcool vinylique) › Enriched Gellan Gum hydrogel as visco-supplement.
questionsmedicales.fr › Phénomènes chimiques › Viscosité › Enriched Gellan Gum hydrogel as visco-supplement.