Effects of rAAV-Mediated
SOX9
cartilage repair
chondrocyte phenotype
osteoarthritis
rAAV
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Oct 2019
07 Oct 2019
Historique:
received:
26
08
2019
revised:
01
10
2019
accepted:
02
10
2019
entrez:
9
10
2019
pubmed:
9
10
2019
medline:
9
10
2019
Statut:
epublish
Résumé
Gene therapy for osteoarthritis offers powerful, long-lasting tools that are well adapted to treat such a slow, progressive disorder, especially those therapies based on the clinically adapted recombinant adeno-associated viral (rAAV) vectors. Here, we examined the ability of an rAAV construct carrying a therapeutic sequence for the cartilage-specific SOX9 transcription factor to modulate the phenotype of human osteoarthritic articular chondrocytes compared with normal chondrocytes in a three-dimensional environment where the cells are embedded in their extracellular matrix. Successful
Identifiants
pubmed: 31591319
pii: jcm8101637
doi: 10.3390/jcm8101637
pmc: PMC6832991
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : German Osteoarthritis Foundation (Deutsche Arthrose-Hilfe e.V.).
ID : MC
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