Sirtuins and SIRT6 in Carcinogenesis and in Diet.
SIRT6
cancer
chemotherapy
diet
modulator
sirtuins
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Oct 2019
07 Oct 2019
Historique:
received:
26
09
2019
accepted:
03
10
2019
entrez:
9
10
2019
pubmed:
9
10
2019
medline:
12
2
2020
Statut:
epublish
Résumé
Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.
Identifiants
pubmed: 31591350
pii: ijms20194945
doi: 10.3390/ijms20194945
pmc: PMC6801518
pii:
doi:
Substances chimiques
SIRT6 protein, human
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE)
ID : M-ERA-NET/0004/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020
Organisme : FCT and Dendropharma - Investigação E Serviços De Intervenção Farmacêutica, Sociedade Unipessoal Lda
ID : PDE/00017/2013
Organisme : The Institute of Nanoscience and Nanotechnology
ID : project ART2018
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