Osteoclastic microRNAs and their translational potential in skeletal diseases.
Osteoclast
Rheumatoid arthritis
microRNA
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
12
04
2019
accepted:
09
09
2019
pubmed:
9
10
2019
medline:
30
4
2020
entrez:
9
10
2019
Statut:
ppublish
Résumé
Skeleton undergoes constant remodeling process to maintain healthy bone mass. However, in pathological conditions, bone remodeling is deregulated, resulting in unbalanced bone resorption and formation. Abnormal osteoclast formation and activation play a key role in osteolysis, such as in rheumatoid arthritis and osteoporosis. As potential therapeutic targets or biomarkers, miRNAs have gained rapidly growing research and clinical attention. miRNA-based therapeutics is recently entering a new era for disease treatment. Such progress is emerging in treatment of skeletal diseases. In this review, we discuss miRNA biogenesis, advances in the strategies for miRNA target identification, important miRNAs involved in osteoclastogenesis and disease models, their regulated mechanisms, and translational potential and challenges in bone homeostasis and related diseases.
Identifiants
pubmed: 31591677
doi: 10.1007/s00281-019-00761-4
pii: 10.1007/s00281-019-00761-4
pmc: PMC7027942
mid: NIHMS1557405
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-582Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR068970
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071463
Pays : United States
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