Syntheses and Functional Studies of Self-Adjuvanting Anti-HER2 Cancer Vaccines.


Journal

Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643

Informations de publication

Date de publication:
02 Dec 2019
Historique:
received: 03 10 2019
pubmed: 9 10 2019
medline: 14 1 2020
entrez: 9 10 2019
Statut: ppublish

Résumé

The 9-mer peptide MFCH401 (N: 165-173: DTILWKDIF), which is located in the extracellular domain of HER2, has been predicted to be a novel epitope. Self-adjuvanting anti-HER2 vaccine constructs were designed and synthesized via covalently attaching MFCH401 or its linear tandem repeats (2×MFCH401, 3×MFCH401) to a lipopeptide Pam

Identifiants

pubmed: 31591824
doi: 10.1002/asia.201901002
doi:

Substances chimiques

Antibodies 0
Cancer Vaccines 0
Cytokines 0
Peptides 0
ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4268-4273

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 15H05836
Organisme : Japan Society for the Promotion of Science
ID : 16H01885
Organisme : Japan Society for the Promotion of Science
ID : 16H05924
Organisme : Japan Society for the Promotion of Science
ID : 17K19201
Organisme : Japan Society for the Promotion of Science
ID : 17H03571

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Qi Feng (Q)

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.

Yoshiyuki Manabe (Y)

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.
Core for Medicine and Science Collaborative Research and Education, Project Research Center for Fundamental Sciences, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.

Kazuya Kabayama (K)

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.
Core for Medicine and Science Collaborative Research and Education, Project Research Center for Fundamental Sciences, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.

Taku Aiga (T)

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.

Asuka Miyamoto (A)

School of Medicine, Tokai University, Isehara, Kanagawa, 259-1193, Japan.

Shino Ohshima (S)

School of Medicine, Tokai University, Isehara, Kanagawa, 259-1193, Japan.

Yoshie Kametani (Y)

School of Medicine, Tokai University, Isehara, Kanagawa, 259-1193, Japan.

Koichi Fukase (K)

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.
Core for Medicine and Science Collaborative Research and Education, Project Research Center for Fundamental Sciences, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan.

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