Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours.
hyperinsulinaemia
hypoglycaemia
neuroendocrine tumour
somatostatinoma
Journal
Endocrinology, diabetes & metabolism
ISSN: 2398-9238
Titre abrégé: Endocrinol Diabetes Metab
Pays: England
ID NLM: 101732442
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
26
10
2018
revised:
07
04
2019
accepted:
24
04
2019
entrez:
9
10
2019
pubmed:
9
10
2019
medline:
9
10
2019
Statut:
epublish
Résumé
Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas. However, the mechanism of hypoglycaemia in patients with somatostatinomas has not been well characterized. We describe two patients with recurrent neuroglycopenic episodes caused by somatostatin-secreting neuroendocrine tumours in the liver, detected by abdominal CTs and whole-body octreotide scintigraphy scans and confirmed by biopsy. Pancreatic islet hyperplasia and co-secretion of insulin (in addition to somatostatin) from tumour cells, respectively, have been characterized as completely distinct mechanisms of hypoglycaemia at both the functional and morphological levels in these two patients. Hypoglycaemia may be caused by different mechanisms in patients with somatostatinomas.
Identifiants
pubmed: 31592116
doi: 10.1002/edm2.83
pii: EDM283
pmc: PMC6775468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e00083Informations de copyright
© 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest in relation to this work.
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