Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review.
ART
autotransplantation
live-birth rate
ovarian stimulation
ovarian tissue cryopreservation
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
24
04
2019
revised:
21
06
2019
accepted:
02
07
2019
pubmed:
9
10
2019
medline:
20
5
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue. Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Not applicable. Women undergoing ovarian tissue transplantation (OTT) and subsequent ART. Literature search in PubMed and Scopus databases. Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures. Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment. The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.
Identifiants
pubmed: 31594631
pii: S0015-0282(19)30581-3
doi: 10.1016/j.fertnstert.2019.07.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
908-921Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.